Altered acetylcholinesterase activity (AChE) and maze performance of developing rats (Rattus norvegicus) following mesencephalic electrical brain stimulation
Lewis, George A.
Preskorn, Sheldon H.
Hughes, Carroll W.
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Lewis, G.A., Preskorn, S.H. & Hughes, C.W. Psychobiology (1978) 6: 53. https://doi.org/10.3758/BF03326691
Cortical arousal was altered by electrical brain stimulation (EBS) to the mesencephalic ascending reticular formation beginning at 27 days of age and administered 2 h/day for either 14 or 28 days. Subjects receiving brain stimulation from 27 to 41 days of age showed a significant decrease in telencephalon AChE activity and weight when compared to controls. These decreases in biochemical and physical parameters corresponded to a marked decrement in maze performance. The advantages and potential uses of the weanling chronic EBS preparation to investigate critical developmental periods are considered.
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