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dc.contributor.authorSrikanth, Madhulika
dc.contributor.authorAsmatulu, Ramazan
dc.contributor.authorCluff, Kim
dc.contributor.authorYao, Li
dc.date.accessioned2019-03-28T19:48:37Z
dc.date.available2019-03-28T19:48:37Z
dc.date.issued2019-03-08
dc.identifier.citationMadhulika Srikanth, Ramazan Asmatulu, Kim Cluff, and Li Yao Material Characterization and Bioanalysis of Hybrid Scaffolds of Carbon Nanomaterial and Polymer Nanofibers ACS Omega 2019 4 (3), 5044-5051en_US
dc.identifier.issn2470-1343
dc.identifier.urihttps://doi.org/10.1021/acsomega.9b00197
dc.identifier.urihttp://hdl.handle.net/10057/15987
dc.description© Author. ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.en_US
dc.description.abstractThe interconnected porous structures that mimic the extracellular matrix support cell growth in tissue engineering. Nanofibers generated by electrospinning can act as a vehicle for therapeutic cell delivery to a neural lesion. The incorporation of carbon nanomaterials with excellent electrical conductivity in nanofibers is an attractive aspect for design of a nanodevice for neural tissue regeneration. In this study, nanoscaffolds were created by electrospinning poly(ϵ-caprolactone) (PCL) and three different types of carbon nanomaterials, which are carbon nanotubes, graphene, and fullerene. The component of carbon nanomaterials in nanofibers was confirmed by Fourier transform infrared spectroscopy. The fiber diameter was determined by scanning electron microscopy, and it was found that the diameter varied depending on the type of nanomaterial in the fibers. The incorporation of carbon nanotubes and graphene in the PCL fibers increased the contact angle significantly, while the incorporation of fullerene reduced the contact angle significantly. Incorporation of CNT, fullerene, and graphene in the PCL fibers increased dielectric constant. Astrocytes isolated from neonatal rats were cultured on PCL-nanomaterial nanofibers. The cell viability assay showed that the PCL-nanomaterial nanofibers were not toxic to the cultured astrocytes. The immunolabeling showed the growth and morphology of astrocytes on nanofiber scaffolds. SEM was performed to determine the cell attachment and interaction with the nanoscaffolds. This study indicates that PCL nanofibers containing nanomaterials are biocompatible and could be used for cell and drug delivery into the nervous system.en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (P20 GM103418) of the National Institutes of Health for support of this study.en_US
dc.language.isoen_USen_US
dc.publisherACSen_US
dc.relation.ispartofseriesACS Omega;v.4:no.3
dc.titleMaterial characterization and bioanalysis of hybrid scaffolds of carbon nanomaterial and polymer nanofibersen_US
dc.typeArticleen_US
dc.rights.holder© 2019 American Chemical Societyen_US


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