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dc.contributor.authorSaeednia, Leyla
dc.contributor.authorYao, Li
dc.contributor.authorCluff, Kim
dc.contributor.authorAsmatulu, Ramazan
dc.date.accessioned2019-03-25T14:49:05Z
dc.date.available2019-03-25T14:49:05Z
dc.date.issued2019-02-22
dc.identifier.citationLeyla Saeednia, Li Yao, Kim Cluff, and Ramazan Asmatulu ACS Omega 2019 4 (2), 4040-4048en_US
dc.identifier.issn2470-1343
dc.identifier.urihttps://doi.org/10.1021/acsomega.8b03212
dc.identifier.urihttp://hdl.handle.net/10057/15977
dc.descriptionACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.en_US
dc.description.abstractInjectable thermosensitive hydrogels have been widely investigated for drug delivery systems. Chitosan (CH) is one of the most abundant natural polymers, and its biocompatibility and biodegradability make it a favorable polymer for thermosensitive hydrogel formation. The addition of nanoparticles can improve its drug release behavior, remote actuation capability, and biological interactions. Carbon nanotubes (CNTs) have been studied for the use in drug delivery systems, and they can act as drug delivery vehicles to improve the delivery of different types of therapeutic agents. In this work, carbon nanotubes were incorporated into a thermosensitive and injectable hydrogel formed by chitosan and β-glycerophosphate (β-GP) (CHâ'β-GP-CNTs). The hybrid hydrogels loaded with methotrexate (MTX) were liquid at room temperature and became a solidified gel at body temperature. A number of tests including scanning electron microscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray diffraction were utilized to characterize the MTX-loaded CHâ'β-GP-CNT hybrid hydrogels. The cell viability (alamarBlue) assay showed that hydrogels containing CNT (0.1%) were not toxic to the 3T3 cells. In vitro MTX release study revealed that CNT-containing hydrogels (with 0.1% CNT) demonstrated a decreased MTX releasing rate compared with control hydrogels without CNT. The cultured MCF-7 breast cancer cells were used to evaluate the efficacy of CHâ'β-GP-CNT hybrid hydrogels delivering MTX on the control of tumor cell growth. Results demonstrated that CNT (0.1%) in the hydrogel enhanced the MTX antitumor function. Our study indicates that a thermosensitive CHâ'β-GP-CNT hybrid hydrogel can be used as a potential breast cancer therapy system for controlled delivery of MTX.en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (P20 GM103418) of the National Institutes of Health for support of this study.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofseriesACS Omega;v.4:no.2
dc.subjectDrug delivery systemsen_US
dc.subjectDrug discovery and drug delivery systemsen_US
dc.subjectNanoclustersen_US
dc.titleSustained releasing of methotrexate from injectable and thermosensitive chitosan-carbon nanotube hybrid hydrogels effectively controls tumor cell growthen_US
dc.typeArticleen_US
dc.rights.holder© 2019 American Chemical Societyen_US


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