Browsing Chemistry and Biochemistry by Type "Dissertation"
Now showing items 1-20 of 56
-
19F-NMR studies on anthrax toxin protective antigen
(Wichita State University, 2014-07)The anthrax protective antigen (PA) is a 83 kDa protein that is one of three protein components of the anthrax toxin, an AB toxin (two-component protein complexes secreted by a number of pathogenic bacteria) secreted by ... -
A new family of small molecules targets anionic phospholipid found in bacterial membrane
(Wichita State University, 2019-07)Antibiotic resistance is one of the most serious threats to human health according to the World Health Organization (WHO). Antibacterial resistance has been around since the development of antibiotics, it is a part of ... -
An investigation of cyanopyrazole ligands and cyanopyrazole scorpionate ligands in the creation of novel transition metal complexes
(Wichita State University, 2022-12)Pyrazole ligands are popular ligands in inorganic and bioinorganic chemistry due to isoelectronic structural isomers of imidazole. Pyrazole ligands can combine with metals to make mononuclear structures, polynuclear ... -
Applications of diffuse reflectance near-infrared spectroscopy and cure kinetics study by differential scanning calorimetry to selected thermosetting polymer-based systems of interest in the aviation industry
(Wichita State University, 2012-05)Diffuse Reflectance Near-Infrared (near-IR) Spectroscopy combined with Partial Least Squares (PLS) regression was used to determine the moisture content and degree of cure in unfilled epoxy resins, carbon-reinforced epoxy ... -
Carbon nanostructured based donor-acceptor conjugates for light-induced energy and electron transfer
(Wichita State University, 2010-12)The research presented in this dissertation deals with the syntheses, characterization, electrochemical, computational and photophysical studies of carbon nanostructures such fullerenes, single-wall carbon nanotubes (SWCNT) ... -
Catecholamine disturbance and SH-SY5Y cell toxicity of halogenated 3-amino-2 phenylpropenes
(Wichita State University, 2009-05)Parkinson’s disease (PD) is a progressive neurodegenerative disease that affects between 1% and 2% of the population over age 65. Despite decades of research and the development of many molecular models of PD, there is ... -
The chemistry of L-ascorbic acid derivatives in the asymmetric synthesis of C2- and C3-substituted aldono-gamma-lactones
(2005-08)The antioxidant and redox properties of L-ascorbic acid are closely associated with the electron rich 2, 3-enediol moiety of the molecule and therefore selective functionalization of the 2- and 3-OH groups is essential for ... -
Cure kinetics and synthesis of some resins and prepreg systems
(Wichita State University, 2009-07)The research reported in this dissertation details the synthesis, characterization and cure kinetics of some resin and prepreg systems. The first chapter gives an introduction to the research presented in this thesis. A ... -
Cyano-substituted polypyrazolylborate metal complexes
(2005-12)Polypyrazolylborates have become one of the most popular ligands used in inorganic and organometallic chemistry. Because of the electron-withdrawing and potential coordination property of the cyano group, as well as the ... -
Delineation of isomers and structural elucidation of macromolecules using high-field ion mobility spectrometry with mass spectrometry
(Wichita State University, 2022-12)Ion Mobility Mass Spectrometry (IMS) is a powerful tool that has been utilized to disentangle components out of a complex mixture, distinguish isomers and elucidate geometries. Linear IMS is based on the absolute mobility ... -
Dengue virus and West Nile virus protease inhibitors
(Wichita State University, 2013-05)Dengue virus and West Nile virus are important mosquito-borne pathogens of Flaviviridae family affecting millions of people worldwide and causing a severe global healthcare threat. However, currently there are no approved ... -
Design, synthesis and biological evaluation of small molecules with potential antibacterial and antiviral activity
(Wichita State University, 2022-05)In recent years, the ongoing explosion of antibiotic-resistance and viral infections has posed a major threat to global public health and called for the development of new therapeutics. Here, a set of novel compounds are ... -
Design, synthesis and evaluation of peptidomimetic inhibitors of severe acute respiratory syndrome coronavirus-2 (sars-cov-2) and Middle East respiratory syndrome coronavirus (mers-cov) proteases
(Wichita State University, 2023-05)SARS-CoV-2 and MERS-CoV president the human coronaviruses and zoonotic coronaviruses due to tremendous repercussions to wellbeing of the world population. Investigational efforts focusing on the disease pathology and viral ... -
Design, synthesis and study of photophysical properties of Re(I) and Ru(II) metal center organometallic complexes as dyes for harvesting sunlight.
(Wichita State University, 2018-07)Due to fascinating physical and photophysical properties, the Re(I) and Ru(II) metal complexes coordinated with small organic molecules, such as 2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyrazine derivatives, are very ... -
Design, synthesis, and biochemical evaluation of novel inhibitors of Norwalk virus 3CL protease
(Wichita State University, 2014-05)Noroviruses are the most common cause of acute gastroenteritis in the US and worldwide, accounting for ~21 million cases of gastroenteritis annually in the US alone. Noroviruses are very stable in the environment and ... -
Diimine complexes of ruthenium(ii), rhenium(i) and iron(ii): from synthesis to DFT studies
(Wichita State University, 2007-08)The chloro and pyridinate derivatives of rhenium(I) tricarbonyl complexes containing the diimine ligands 2,2’-bipyrazine (bpz) and 5,5’-dimethyl-2,2’-bipyrazine (Me2bpz) are discussed. When compared to similar rhenium(I) ... -
Enhancing detection sensitivity for measuring amino neurotransmitters with flow-gated capillary electrophoresis
(Wichita State University, 2020-07)Capillary electrophoresis (CE) commences as a promising technique for analyzing a variety of biological substances and has been used in bioanalytical and biopharmaceutical applications. Flow-gated CE has numerous advantages ... -
Enhancing the performance of an epoxy resin using oligomeric amide additives
(Wichita State University, 2012-05)An antiplasticizer is any chemical that when added, reduces the free volume of a polymer thereby restricting the polymeric chain motions. This type of additive usually increases the modulus and strength but can compromise ... -
Flow-gated capillary electrophoresis for rapid analysis of biological samples
(Wichita State University, 2016-07)Capillary electrophoresis (CE) and related technologies have been utilized with great success for a variety of bioanalytical applications. CE has the advantages of decreased analysis time, integrated sample processing, ... -
Fragmentation of model peptides by collision-activated dissociation
(Wichita State University, 2009-07)Novel fragmentation pathways of various model peptides were generated by collision-induced dissociation (CID) mass spectrometry. For the series AXAG where X=ßA, γAbu, εCap, or 4AMBz, the CID of the [b₃-1+Cat]⁺ where the ...