Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.

We describe herein the design, synthesis, and in vitro biochemical evaluation of a series of potent, time-dependent inhibitors of the mast cell-derived serine protease tryptase. The inhibitors were readily obtained by ...

The anthrax protective antigen (PA) is a 83 kDa protein that is one of three protein components of the anthrax toxin, an AB toxin (two-component protein complexes secreted by a number of pathogenic bacteria) secreted by ...

Specific uptake through dopamine transporter followed by the inhibition of the mitochondrial complex-I have been accepted as the cause of the specific dopaminergic toxicity of 1-methyl-4-phenylpyridinium (MPP+). However, ...

The title compound, C(6)H(8)FN(3)O(2), an analog of histidine, shows a reduced side-chain pK(a) (ca 1). The title structure exhibits a shortening of the bond between the proximal ring N atom and the F-substituted ring C ...

Pathogenic coronaviruses are a major threat to global public health, as exemplified by severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the newly emerged ...

Sensitive and selective detection of biologically and environmentally important anions has been a vast growing field in supramolecular chemistry [1,2]. Much research has been devoted to designing sensors that can selectively ...

Twenty-six writing inks have been examined, with the purpose of comparing them with those examined by Munson in l906, and of ascertaining their relative merits . Collectively, they prove equal to the older inks. So far as ...