Browsing Chemistry by Subject "Main protease"

Now showing items 1-2 of 2

    • Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses 

      Kim, Yunjeong; Shivanna, Vinay; Narayanan, Sanjeev; Prior, Allan M.; Weerasekara, Sahani; Hua, Duy H.; Kankanamalage, Anushka C. Galasiti; Groutas, William C.; Chang, Kyeong-Ok (American Society for Microbiology, 2015-05)
      Feline infectious peritonitis and virulent, systemic calicivirus infection are caused by certain types of feline coronaviruses (FCoVs) and feline caliciviruses (FCVs), respectively, and are important infectious diseases ...

    • Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor 

      Kim, Yunjeong; Liu, Hongwei; Kankanamalage, Anushka C. Galasiti; Weerasekara, Sahani; Hua, Duy H.; Groutas, William C.; Chang, Kyeong-Ok; Pedersen, Niels C. (Public Library of Science Pathogens, 2016-03-30)
      Coronaviruses infect animals and humans causing a wide range of diseases. The diversity of coronaviruses in many mammalian species is contributed by relatively high mutation and recombination rates during replication. This ...