Browsing Chemistry by Subject "Bacterial Toxins/metabolism"

Now showing items 1-4 of 4

    • Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation 

      Wimalasena, D. Shyamali; Cramer, John C.; Janowiak, Blythe E.; Juris, Stephen J.; Melnyk, Roman A.; Anderson, David E.; Kirk, Kenneth L.; Collier, R. John; Bann, James G. (American Chemical Society, 2007-12-25)
      The action of anthrax toxin relies in part upon the ability of the protective antigen (PA) moiety to form a heptameric pore in the endosomal membrane, providing a portal for entry of the enzymic moieties of the toxin into ...

    • Evidence that histidine protonation of receptor-bound anthrax protective antigen is a trigger for pore formation 

      Wimalasena, D. Shyamali; Janowiak, Blythe E.; Lovell, Scott; Miyagi, Masaru; Sun, Jianjun; Zhou, Haiying; Hajduch, Jan; Pooput, Chaya; Kirk, Kenneth L.; Battaile, Kevin P.; Bann, James G. (American Chemical Society, 2010-08-24)
      The protective antigen (PA) component of the anthrax toxin forms pores within the low pH environment of host endosomes through mechanisms that are poorly understood. It has been proposed that pore formation is dependent ...

    • LRP6 holds the key to the entry of anthrax toxin 

      Bann, James G.; Cegelski, Lynette; Hultgren, Scott J. (Elsevier, 2006-03-24)
      In this issue of Cell, it is demonstrated that the low-density lipoprotein receptor-related protein 6 (LRP6) promotes endocytosis of the anthrax toxin into cells. LRP6 acts as a coreceptor with either TEM8 or CMG2, the two ...

    • Monitoring anthrax toxin receptor dissociation from the protective antigen by NMR 

      Rajapaksha, Maheshinie; Eichler, Jack F.; Hajduch, Jan; Anderson, David E.; Kirk, Kenneth L.; Bann, James G. (John Wiley and Sons, 2009-01-01)
      The binding of the Bacillus anthracis protective antigen (PA) to the host cell receptor is the first step toward the formation of the anthrax toxin, a tripartite set of proteins that include the enzymatic moieties edema ...