Browsing Chemistry and Biochemistry by Author "Yadav, Rahul"
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Actin polymerization is stimulated by actin cross-linking protein palladin
Gurung, Ritu; Yadav, Rahul; Brungardt, Joseph G.; Orlova, Albina; Egelman, Edward H.; Beck, Moriah R. (Portland Press Limited, 2016-02-09)The actin scaffold protein palladin regulates both normal cell migration and invasive cell motility, processes that require the co-ordinated regulation of actin dynamics. However, the potential effect of palladin on actin ... -
Actin-induced dimerization of palladin promotes actin-bundling
Vattepu, Ravi; Yadav, Rahul; Beck, Moriah R. (John Wiley & Sons, Inc., 2015-01)A subset of actin binding proteins is able to form crosslinks between two or more actin filaments, thus producing structures of parallel or networked bundles. These actin crosslinking proteins interact with actin through ... -
Palladin Nucleates Actin Assembly and Regulates Cytoskeleton Architecture
Gurung, Ritu; Vattepu, Ravi; Yadav, Rahul; Beck, Moriah R. (Elsevier Inc., 2015-01-27)The actin scaffold protein palladin regulates both normal cell migration and invasive cell motility, processes that require the coordinated regulation of actin dynamics. Palladin localizes to actin-rich protrusions and has ... -
Palladin's Ig4 Mutation: Exploring the link with pancreatic cancer
Saiz, Stan; Dille, Joseph; Yadav, Rahul; Beck, Moriah R. (Elsevier Inc., 2015-01-27)Palladin is a recently discovered protein that is expressed in human cells and plays a key role in cytoskeletal dynamics by directly binding and bundling filaments of actin. These processes provide an important function ... -
Phosphoinositide binding inhibits actin crosslinking and polymerization by palladin
Yadav, Rahul; Vattepu, Ravi; Beck, Moriah R. (Elsevier B.V., 2016-10-09)Actin cytoskeleton remodeling requires the coordinated action of a large number of actin binding proteins that reorganize the actin cytoskeleton by promoting polymerization, stabilizing filaments, causing branching, or ...