Browsing Chemistry and Biochemistry by Author "Taylor, Derek J."

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Advances in structure determination by cryo-EM to unravel membrane-spanning pore formation

Scott, Harry; Huang, Wei; Bann, James G.; Taylor, Derek J. (John Wiley and Sons, 2018-08-20)

The beta pore-forming proteins (-PFPs) are a large class of polypeptides that are produced by all Kingdoms of life to contribute to their species' own survival. Pore assembly is a sophisticated multi-step process that ...
Structure of the anthrax protective antigen D425A dominant negative mutant reveals a stalled intermediate state of pore maturation

Scott, Harry; Huang, Wei; Andra, Kiran K.; Mamillapalli, Sireesha; Gonti, Srinivas; Day, Alexander; Zhang, Kaiming; Mehzabeen, Nurjahan; Battaile, Kevin P.; Raju, Anjali; Lovell, Scott; Bann, James G.; Taylor, Derek J. (Elsevier, 2022-05-15)

The tripartite protein complex produced by anthrax bacteria (Bacillus anthracis) is a member of the AB family of β-barrel pore-forming toxins. The protective antigen (PA) component forms an oligomeric prepore that assembles ...