Now showing items 1-2 of 2

    • 3-(Alkylthio)-N-hydroxysuccinimide derivatives: potent inhibitors of human leukocyte elastase 

      Groutas, William C.; Venkataraman, Radhika; Brubaker, Michael J.; Epp, Jeffrey B.; Chong, Lee S.; Stanga, Michael A.; McClenahan, Jerald J.; Tagusagawa, F. (Elsevier, 1993-08-07)
      A series of 3-(alkylthio)-N-hydroxysuccinimide derivatives was synthesized and their inhibitory activity towards human leukocyte elastase (HLE) was investigated. The interaction of the compounds having a 3-alkylthioether ...
    • Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils 

      Groutas, William C.; Huang, He; Epp, Jeffrey B.; Venkataraman, Radhika; McClenahan, Jerry J.; Tagusagawa, F. (Elsevier, 1994-11-29)
      A series of dihydrouracil derivatives has been synthesized and investigated for their in vitro inhibitory activity toward human leukocyte elastase (HLE) and cathepsin G (Cath G). Alkyl [sulfonyl(oxy)] uracils 1-2 were found ...