Browsing Chemistry and Biochemistry by Author "Schechter, Norman M."
1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase Wong, Tzutshin; Groutas, Christopher S.; Mohan, Swathi; Lai, Zhong; Alliston, Kevin R.; Vu, Nga T.; Schechter, Norman M.; Groutas, William C. (Elsevier, 2005-04-01)We describe herein the design, synthesis, and in vitro biochemical evaluation of a series of potent, time-dependent inhibitors of the mast cell-derived serine protease tryptase. The inhibitors were readily obtained by ...
Groutas, William C.; Schechter, Norman M.; He, Shu; Yu, Hongyi; Huang, Peng; Tu, Juan (Elsevier, 1999-08-02)A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase.
Inhibition of human tryptase by 1, 2, 5 - thiadiazolidin-3-one 1, 1 dioxide-based heterocyclic sulfides Mohan, Swathi; Wong, Tzutshin; Groutas, Christopher S.; Lai, Zhong; Alliston, Kevin R.; Vu, Nga T.; Schechter, Norman M.; Groutas, William C. (Wichita State University. Graduate School., 2005-04-22)