Browsing Chemistry and Biochemistry by Author "Samms, Warren C."

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Catecholamine disturbance and SH-SY5Y cell toxicity of halogenated 3-amino-2 phenylpropenes

Samms, Warren C. (Wichita State University, 2009-05)

Parkinson’s disease (PD) is a progressive neurodegenerative disease that affects between 1% and 2% of the population over age 65. Despite decades of research and the development of many molecular models of PD, there is ...
Perturbation of dopamine metabolism by 3-amino-2-(4'-halophenyl)propenes leads to increased oxidative stress and apoptotic SH-SY5Y cell death

Samms, Warren C.; Perera, Rohan P.; Wimalasena, D. Shyamali; Wimalasena, Kandatege (American Society for Pharmacology and Experimental Therapeutics, 2007-09-01)

We have recently characterized a series of 3-amino-2-phenyl-propene (APP) derivatives as reversible inhibitors for the bovine adrenal chromaffin granule vesicular monoamine transporter (VMAT) that have been previously ...
A study on the mechanism of the Parkinsonian-causing drug 1-methyl-4-phenylpyridinium (MPP+)

Samms, Warren C.; Perera, Rohan P.; Wimalasena, D. Shyamali; Turla, K.M.; Wimalasena, Kandatege (Wichita State University, 2005-04-22)