Now showing items 1-2 of 2

    • Structure-guided design of potent inhibitors of SARS-CoV-2 3CL protease: Structural, biochemical, and cell-based studies 

      Dampalla, Chamandi S.; Rathnayake, Athri D.; Perera, Krishani Dinali; Jesri, Abdul Rahman M.; Nguyen, Harry Nhat; Miller, Matthew J.; Thurman, Hayden A.; Zheng, Jian; Kashipathy, Maithri M.; Battaile, Kevin P.; Lovell, Scott; Perlman, Stanley (American Chemical Society, 2021-12-01)
      The COVID-19 pandemic is having a major impact on public health worldwide, and there is an urgent need for the creation of an armamentarium of effective therapeutics, including vaccines, biologics, and small-molecule ...
    • Structure-guided optimization of dipeptidyl inhibitors of Norovirus 3CL protease 

      Rathnayake, Athri D.; Kim, Yunjeong; Dampalla, Chamandi S.; Nguyen, Harry Nhat; Jesri, Abdul Rahman M.; Kashipathy, Maithri M.; Lushington, Gerald Henry; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. (American Chemical Society, 2020-09-18)
      Acute gastroenteritis caused by noroviruses has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The disease impacts most severely immunocompromised patients, the elderly, ...