Browsing Chemistry and Biochemistry by Author "Jayasinghe, Champika P."

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A convenient, one-step synthesis of benzyl (Ar) ureas of the type ArCH(2)NHCONHR from Ar and R(1)OCH(2)NHCONHR via ureidoalkylation

Meece, Frederick A.; Jayasinghe, Champika P.; Histand, Gary; Burns, Dennis H. (American Chemical Society, 2009-04-17)

A method for the one-step C-ureidoalkylation of phenol, anisole, or aniline rings furnishing ArCH(2)NHCONHR (Ar = benzyl) products in moderate to good yields is described. With phenol ring systems, higher yields were ...
Synthesis and characterization of picket porphyrin receptors that bind phosphatidylglycerol, an anionic phospholipid found in bacterial membranes

Alliband, Amanda M.; Meece, Frederick A.; Jayasinghe, Champika P.; Burns, Dennis H. (American Chemical Society, 2013-01-18)

The lipid binding ability of four urea-picket porphyrins designed to bind to both the phosphate anion portion as well as the glycerol hydroxyl groups of phosphatidylglycerol (PG) has been investigated. Isothermal titration ...
Synthesis and characterization of receptors to bind anionic components of bacterial membranes

Jayasinghe, Champika P. (Wichita State University, 2012-05)

Small molecules that can selectively recognize phospholipids would likely be useful as tools for chemical biology and may have application as pharmaceuticals. Inspired by the phospholipid binding of antimicrobial peptids ...