Browsing Chemistry and Biochemistry by Author "Janowiak, Blythe E."
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Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation
Wimalasena, D. Shyamali; Cramer, John C.; Janowiak, Blythe E.; Juris, Stephen J.; Melnyk, Roman A.; Anderson, David E.; Kirk, Kenneth L.; Collier, R. John; Bann, James G. (American Chemical Society, 2007-12-25)The action of anthrax toxin relies in part upon the ability of the protective antigen (PA) moiety to form a heptameric pore in the endosomal membrane, providing a portal for entry of the enzymic moieties of the toxin into ... -
Evidence that histidine protonation of receptor-bound anthrax protective antigen is a trigger for pore formation
Wimalasena, D. Shyamali; Janowiak, Blythe E.; Lovell, Scott; Miyagi, Masaru; Sun, Jianjun; Zhou, Haiying; Hajduch, Jan; Pooput, Chaya; Kirk, Kenneth L.; Battaile, Kevin P.; Bann, James G. (American Chemical Society, 2010-08-24)The protective antigen (PA) component of the anthrax toxin forms pores within the low pH environment of host endosomes through mechanisms that are poorly understood. It has been proposed that pore formation is dependent ... -
pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2
Rajapaksha, Maheshinie; Lovell, Scott; Janowiak, Blythe E.; Andra, Kiran K.; Battaile, Kevin P.; Bann, James G. (Wiley-Blackwell, 2012-10)The anthrax protective antigen (PA) binds to the host cellular receptor capillary morphogenesis protein 2 (CMG2) with high affinity. To gain a better understanding of how pH may affect binding to the receptor, we have ...