Browsing Chemistry and Biochemistry by Author "Jacobs, Donald J."

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    • Characterizing dynamical differences between TEM-1 and TEM-52 beta-lactamases 

      Avery, Christopher; Farmer, Jenny; Tsilimigras, Matthew C. B.; David, Charles; Livesay, Dennis R.; Jacobs, Donald J. (Cell Press, 2019-02-15)
      Beta-lactamase, produced in bacteria, defends against beta-lactam antibiotics such as penicillin and cephalosporins by hydrolyzing the beta-lactam ring. This is a primary cause of antibiotic resistance to beta-lactam ...

    • Evolution of stability/flexibility relationships in beta-lactamase 

      Patterson, John; Tsilimigras, Matthew C. B.; Livesay, Dennis R.; Jacobs, Donald J. (Cell Press, 2019-02-15)
      We have curated over 100 structures of class A beta-lactamase proteins, a family of enzymes that is responsible for a considerable percentage of multidrug antibiotic resistance in bacteria. Our dataset includes three ...