Browsing Chemistry and Biochemistry by Author "Gunnam, Mallikarjuna Reddy"

Now showing items 1-6 of 6

    • Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease 

      Tiew, Kok-Chuan; He, Guijia; Aravapalli, Sridhar; Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (Elsevier, 2011-09-15)
      The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The ...

    • Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors 

      Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Tiew, Kok-Chuan; Uy, Roxanne Adeline Z.; Prior, Allan M.; Alliston, Kevin R.; Hua, Duy H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (PERGAMON-ELSEVIER SCIENCE LTD, 2013-01)
      Noroviruses are the most common cause of acute viral gastroenteritis, accounting for >21 million cases annually in the US alone. Norovirus infections constitute an important health problem for which there are no specific ...

    • Novel anti-norovirus therapeutics 

      Gunnam, Mallikarjuna Reddy (Wichita State University, 2013-05)
      Noroviruses are the most common cause of acute gastroenteritis, accounting for over 23 million cases annually in the U.S. alone. Norovirus infections constitute an important health problem for which there are no specific ...

    • Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles 

      Mandadapu, Sivakoteswara Rao; Weerawarna, Pathum M.; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (Elsevier, 2012-05-26)
      A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a ...

    • Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics 

      Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Kankanamalage, Anushka C. Galasiti; Uy, Roxanne Adeline Z.; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (Elsevier, 2013-11)
      The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme ...

    • Potent norovirus inhibitors based on the acyclic sulfamide scaffold 

      Dou, Dengfeng; Tiew, Kok-Chuan; Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (Elsevier, 2012-03-15)
      The development of small molecule therapeutics to combat norovirus infection is of considerable interest from a public health perspective because of the highly contagious nature of noroviruses. A series of amino acid-derived ...