Browsing Chemistry and Biochemistry by Author "Groutas, Christopher S."
Now showing items 1-5 of 5
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1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase
Wong, Tzutshin; Groutas, Christopher S.; Mohan, Swathi; Lai, Zhong; Alliston, Kevin R.; Vu, Nga T.; Schechter, Norman M.; Groutas, William C. (Elsevier, 2005-04-01)We describe herein the design, synthesis, and in vitro biochemical evaluation of a series of potent, time-dependent inhibitors of the mast cell-derived serine protease tryptase. The inhibitors were readily obtained by ... -
Inhibition of human tryptase by 1, 2, 5 - thiadiazolidin-3-one 1, 1 dioxide-based heterocyclic sulfides
Mohan, Swathi; Wong, Tzutshin; Groutas, Christopher S.; Lai, Zhong; Alliston, Kevin R.; Vu, Nga T.; Schechter, Norman M.; Groutas, William C. (Wichita State University. Graduate School., 2005-04-22) -
Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents
Yang, Qingliang; Li, Yi; Dou, Dengfeng; Gan, Xiangdong; Mohan, Swathi; Groutas, Christopher S.; Stevenson, Laura E.; Lai, Zhong; Alliston, Kevin R.; Zhong, Jiaying; Williams, Todd D.; Groutas, William C. (Elsevier, 2008-07-15)A new class of carbamylating agents based on the cyclosulfamide scaffold is reported. These compounds were found to be efficient time-dependent inhibitors of human neutrophil elastase (HNE). Exploitation of the three sites ... -
Potential protease inhibitors based on a functionalized cyclic sulfamide scaffold
Zhong, Jiaying; Gan, Xiangdong; Alliston, Kevin R.; Lai, Zhong; Yu, Hongyi; Groutas, Christopher S.; Wong, Tzutshin; Groutas, William C. (American Chemical Society, 2004-07-01)Exploratory studies related to the design and synthesis of functionalized cyclic sulfamides (I) as potential inhibitors of proteolytic enzymes were carried out. The structural motif and three diversity sites embodied in ... -
Serendipitous discovery of an unexpected rearrangement leads to two new classes of potential protease inhibitors
Zhong, Jiaying; Lai, Zhong; Groutas, Christopher S.; Wong, Tzutshin; Gan, Xiangdong; Alliston, Kevin R.; Eichhorn, David M.; Hoidal, John R.; Groutas, William C. (Elsevier, 2004-12-01)The pathogenesis of a range of human diseases arises from the aberrant activity of proteolytic enzymes. Agents capable of selectively modulating the activity of these enzymes are of potential therapeutic value. Thus, there ...