Now showing items 1-2 of 2

    • Characterization of complete histone tail proteoforms using differential ion mobility spectrometry 

      Shliaha, Pavel V.; Baird, Matthew A.; Nielsen, Mogens M.; Gorshkov, Vladimir A.; Bowman, Andrew P.; Kaszycki, Julia L.; Jensen, Ole N.; Shvartsburg, Alexandre A. (American Chemical Society, 2017-05-16)
      Histone proteins are subject to dynamic post-translational modifications (PTMs) that cooperatively modulate the chromatin structure and function. Nearly all functional PTMs are found on the N-terminal histone domains (tails) ...
    • Middle-down proteomic analyses with Ion mobility separations of endogenous isomeric proteoforms 

      Shliaha, Pavel V.; Gorshkov, Vladimir A.; Kovalchuk, Sergey I.; Schwammle, Veit; Baird, Matthew A.; Shvartsburg, Alexandre A.; Jensen, Ole N. (NLM (Medline), 2020-01-14)
      Biological functions of many proteins are governed by post-translational modifications (PTMs). In particular, the rich PTM complement in histones controls the gene expression and chromatin structure with major health ...