Browsing Chemistry and Biochemistry by Author "Gonti, Srinivas"
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$^{19}F$-NMR studies to understand pH induced structural changes in protective antigen anthrax toxin
Gonti, Srinivas; Westler, William M.; Miyagi, Masaru (Wichita State University, 2022-04-29)Anthrax bacteria ($Bacillus$ $anthracis$) produces Protective antigen toxin (PA), Lethal factor (LF) and Edema factor (EF) protein components into the host cells. Protective antigen toxin (PA83 - 83kDa polypeptide) binds ... -
Binding of the von Willebrand factor A domain of capillary morphogenesis protein 2 to anthrax protective antigen vaccine reduces immunogenicity in mice
de Oliveira, Fabiana Freire Mendes; Mamillapalli, Sireesha; Gonti, Srinivas; Brey, Robert N.; Li, Han; Schiffer, Jarad M.; Casadevall, Arturo; Bann, James G. (NLM (Medline), 2020-01)Protective antigen (PA) is a component of anthrax toxin that can elicit toxin-neutralizing antibody responses. PA is also the major antigen in the current vaccine to prevent anthrax, but stability problems with recombinant ... -
Structure of the anthrax protective antigen D425A dominant negative mutant reveals a stalled intermediate state of pore maturation
Scott, Harry; Huang, Wei; Andra, Kiran K.; Mamillapalli, Sireesha; Gonti, Srinivas; Day, Alexander; Zhang, Kaiming; Mehzabeen, Nurjahan; Battaile, Kevin P.; Raju, Anjali; Lovell, Scott; Bann, James G.; Taylor, Derek J. (Elsevier, 2022-05-15)The tripartite protein complex produced by anthrax bacteria (Bacillus anthracis) is a member of the AB family of β-barrel pore-forming toxins. The protective antigen (PA) component forms an oligomeric prepore that assembles ...