Browsing Chemistry and Biochemistry by Title
Now showing items 572-591 of 691
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Structure-guided design and optimization of dipeptidyl inhibitors of Norovirus 3CL protease. Structure-activity relationships and biochemical, x-ray crystallographic, cell-based, and in vivo studies
(American Chemical Society, 2015-04-09)Norovirus infection constitutes the primary cause of acute viral gastroenteritis. There are currently no vaccines or norovirus-specific antiviral therapeutics available for the management of norovirus infection. Norovirus ... -
Structure-guided design of conformationally constrained cyclohexane inhibitors of severe acute respiratory syndrome coronavirus-2 3cl protease
(American Chemical Society, 2021-07-01)A series of nondeuterated and deuterated dipeptidyl aldehyde and masked aldehyde inhibitors that incorporate in their structure a conformationally constrained cyclohexane moiety was synthesized and found to potently inhibit ... -
Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)
(Elsevier Ltd, 2023-06-05)The high morbidity and mortality associated with SARS-CoV-2 infection, the etiological agent of COVID-19, has had a major impact on global public health. Significant progress has been made in the development of an array ... -
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
(Elsevier, 2018-04-25)There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections. MERS-CoV 3CL protease is essential ... -
Structure-guided design of potent inhibitors of SARS-CoV-2 3CL protease: Structural, biochemical, and cell-based studies
(American Chemical Society, 2021-12-01)The COVID-19 pandemic is having a major impact on public health worldwide, and there is an urgent need for the creation of an armamentarium of effective therapeutics, including vaccines, biologics, and small-molecule ... -
Structure-guided design of potent spirocyclic inhibitors of severe acute respiratory syndrome coronavirus-2 3C-like protease
(American Chemical Society, 2022-06-09)The worldwide impact of the ongoing COVID-19 pandemic on public health has made imperative the discovery and development of direct-acting antivirals aimed at targeting viral and/or host targets. SARS-CoV-2 3C-like protease ... -
Structure-guided design, synthesis and evaluation of macrocyclic and peptidomimetic inhibitors of viral proteases
(Wichita State University, 2017-07)Human noroviruses are the primary cause of non-bacterial acute gastroenteritis worldwide and are associated with high morbidity and a heavy economic burden. In the U.S. alone noroviruses account for ~21 million cases, ... -
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease
(Elsevier, 2018-01-01)Acute nonbacterial gastroenteritis caused by noroviruses constitutes a global public health concern and a significant economic burden. There are currently no small molecule therapeutics or vaccines for the treatment of ... -
Structure-guided design, synthesis, x-ray crystallography, and biochemical and in vivo evaluation of novel series of viral 3cl protease inhibitors of norovirus (NV) and Middle East Respiratory Distress Syndrome coronavirus (MERS-CoV)
(Wichita State University, 2017-07)Norovirus infection constitutes the primary cause of acute viral gastroenteritis. There are currently no vaccines or norovirus-specific antiviral therapeutics available for the management of norovirus infection. Norovirus ... -
Structure-guided optimization of dipeptidyl inhibitors of Norovirus 3CL protease
(American Chemical Society, 2020-09-18)Acute gastroenteritis caused by noroviruses has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The disease impacts most severely immunocompromised patients, the elderly, ... -
Studies on electron and energy transfer in porphyrin and fullerene based systems
(2006-05)The research presented in this thesis deals with the synthesis, optical and photochemical studies of various porphyrin and/or fullerene based systems. The second chapter deals with the study of fullerene based molecules ... -
Studies on porphyrin-quinhydrone complexes: molecular recognition of quinone and hydroquinone in solution
(American Chemical Society, 2001-06-29)Free-base and zinc(II) porphyrins bearing either one, two, or four hydroquinone entities at the meso positions are shown to bind quinones in solutions via a quinhydrone pairing mechanism. Electrochemical studies reveal ... -
Studies on self-assembled porphyrin-fullerene and porphyrin-carbon nanotube donor-acceptor conjugates
(Wichita State University, 2007-12)The research presented in this dissertation deals with the syntheses, characterization, electrochemical and photophysical studies of porphyrin-fullerene or porphyrin-carbon nanotube based donor-acceptor conjugates. The ... -
Studies towards small-molecule-receptors selective for phospholipid anionic head groups in bacterial membranes
(Wichita State University, 2009-05)Receptors specific for inorganic anions have been described for several decades. Several of these anions, i.e. chloride, phosphate, and acetate are essential in biology. A novel neutral anion receptor specific for the ... -
The study and application of biomolecules in deep eutectic solvents
(Royal Society of Chemistry, 2021-01)Biomolecules have been thoroughly investigated in a multitude of solvents historically in order to accentuate or modulate their superlative properties in an array of applications. Ionic liquids have been extensively explored ... -
Study of abeta aggregates as a diagnostic target and TREM2 as a potential therapeutic target in Alzheimer’s disease
(Wichita State University, 2023-05)Alzheimer’s disease is a neurological disorder and the most common cause of dementia. When considering the pathology of Alzheimer’s disease, Aβ plaques are one of the major pathological hallmarks of Alzheimer’s disease. ... -
A study of fragmentation of protonated amides of some acylated amino acids by tandem mass spectrometry: observation of an unusual nitrilium ion
(John Wiley and Sons, 2011-05-15)A tandem mass spectrometric study of a series of secondary amides of acetylglycine and hippuric acid utilizing electrospray ionization (ESI) was conducted. Among the fragment ions observed was an unusual one, which we have ... -
Study of photoinduced electron transfer of tris(phenothiazine) subphthalocyanine-fullerene pentad for light energy harvesting system
(American Chemical Society, 2014-03-16)Photo induced excitation and electron transfer to reaction center generate long lived charge separated state is the key step for natural photosynthesis process in green plants to harvest light energy. Well-arranged donor ... -
A study of the elimination of water from lithium-cationized tripeptide methyl esters by means of tandem mass spectrometry and isotope labeling
(John Wiley and Sons, 2006-01-01)Extensive isotope labeling (2H, 13C and 15N), collision-induced dissociation (CID) and multiple-stage tandem mass spectrometry were used to investigate the elimination of H2O from a series of model, metal-cationized ... -
A study on the mechanism of the Parkinsonian-causing drug 1-methyl-4-phenylpyridinium (MPP+)
(Wichita State University, 2005-04-22)