Browsing Chemistry and Biochemistry by Title
Now showing items 465-484 of 675
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Polypyridyl complexes of uracil derivatives attached to 2,2 '-pyridyl
(American Chemical Society, 2018)Three ligands obtained by the condensation of 2,2'-pyridyl with 5,6-diaminouracil, 5,6-diamino-1-methyluracil and 5,6-diamino-1,3-dimethyluracil were synthesized and crystal structures of the uracil and di-Me ... -
Porphyrin molecules that selectively bind to the phosphatidylglycerol (PG) head group, a lipid found in bacterial membrane
(Wichita State University, 2019-04-26)Porphyrin molecules that selectively bind to the phosphatidylglycerol (PG) head group, a lipid found in bacterial membrane have been previously reported by our research group. A tetrakis-ammonium glycine picket porphyrin ... -
Potassium ion controlled switching of intra- to intermolecular electron transfer in crown ether appended free-base porphyrin-fullerene donor-acceptor systems
(American Chemical Society, 2006-04-06)Photoinduced electron transfer in intramolecularly interacting free-base porphyrin bearing one or four 18-crown-6 ether units at different positions of the porphyrin macrocycle periphery and pristine fullerene was investigated ... -
Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
(Elsevier, 1998-06-01)This paper describes the results of structure-activity relationship studies in a series of heterocyclic mechanism-based inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold I and capable of interacting ... -
Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and alpha-ketoamides
(Elsevier Ltd., 2016-01)Enterovirus D68 (EV-D68) is an emerging pathogen responsible for mild to severe respiratory infections that occur mostly in infants, children and teenagers. EV-D68, one of more than 100 non-polio enteroviruses, is acid-labile ... -
Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease
(Elsevier, 2012-11-28)Feline coronavirus infection is common among domestic and exotic felid species and usually associated with mild or asymptomatic enteritis; however, feline infectious peritonitis (FIP) is a fatal disease of cats that is ... -
Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives
(Elsevier, 2004-09-15)The design, synthesis, and in vitro biochemical evaluation of a class of mechanism-based inhibitors of human leukocyte elastase (HLE) that incorporate in their structure a 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold ... -
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
(Elsevier, 2012-05-26)A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a ... -
Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics
(Elsevier, 2013-11)The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme ... -
Potent inhibition of Norwalk virus by cyclic sulfamide derivatives
(Elsevier, 2011-10-15)A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED(50) 4 µM, ... -
Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide
(Elsevier, 2000-07-01)The existence of subtle differences in the Sn' subsites of closely-related (chymo)trypsin-like serine proteases, and the fact that the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold docks to the active site of (chymo)trypsin-like ... -
Potent norovirus inhibitors based on the acyclic sulfamide scaffold
(Elsevier, 2012-03-15)The development of small molecule therapeutics to combat norovirus infection is of considerable interest from a public health perspective because of the highly contagious nature of noroviruses. A series of amino acid-derived ... -
Potent protease inhibitors of highly pathogenic lagoviruses: Rabbit hemorrhagic disease virus and European brown hare syndrome virus
(American Society for Microbiology, 2022-06-29)Rabbit hemorrhagic disease (RHD) and European brown hare syndrome (EBHS) are highly contagious diseases caused by lagoviruses in the Caliciviridae family. These infectious diseases are associated with high mortality and a ... -
Potential inhibitors of COPD-relevant serine proteases based on the N-amino-4-imidazolidinone scaffold
(Wichita State University, 2009-12)Human neutrophil elastase (HNE) and proteinase 3 (PR3) are serine proteases which play a crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD), a multifactorial disorder associated with an imbalance ... -
Potential protease inhibitors based on a functionalized cyclic sulfamide scaffold
(American Chemical Society, 2004-07-01)Exploratory studies related to the design and synthesis of functionalized cyclic sulfamides (I) as potential inhibitors of proteolytic enzymes were carried out. The structural motif and three diversity sites embodied in ... -
Prediction of selectivity for the separation of double-stranded DNA fragments in electrophoresis
(ISC Technical Publications, 1997-09-01)The electrophoretic resolution (selectivity) of double-stranded DNA (dsDNA) restriction fragments is studied for different organisms (phi X174, lambda phage, and pGEM-3 plasmids) by various separation and detection methods. ... -
The preparation of charged anion receptors to bind anionic components of bacterial membranes
(Wichita State University. Graduate School, 2010-04-23)A receptor able to selectively bind a phosphatidylglycerol (PPG) head group is an attractive synthetic target as a modular component of an antimicrobial therapeutic. The major challenge to the preparation of such receptors, ... -
Preparation, Purification, and Characterization of Binuclear Ruthenium(II) Complexes: Bridging Ligands Based on Diazafluorenes
(American Chemical Society, 1998-05-04)A series of bimetallic complexes of ruthenium(II) bridged by heterocyclic ligands formed by the condensation of 4,5-diazafluoren-9-one with various diamines, hydrazine, 1,4-phenylenediamine, benzidine, and 4,4'-methylenedianiline, ... -
A priori intrinsic PTM size parameters for predicting the ion mobilities of modified peptides
(Springer International Publishing, 2017-02)The rising profile of ion mobility spectrometry (IMS) in proteomics has driven the efforts to predict peptide cross-sections. In the simplest approach, these are derived by adding the contributions of all amino acid residues ... -
Probing adaptation of hydration and protein dynamics to temperature
(American Chemical Society, 2022-06-28)Protein dynamics is strongly influenced by the surrounding environment and physiological conditions. Here we employ broadband megahertz-to-terahertz spectroscopy to explore the dynamics of water and myoglobin protein on ...