Browsing Chemistry and Biochemistry by Title
Now showing items 416-435 of 671
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Novel anti-norovirus therapeutics
(Wichita State University, 2013-05)Noroviruses are the most common cause of acute gastroenteritis, accounting for over 23 million cases annually in the U.S. alone. Norovirus infections constitute an important health problem for which there are no specific ... -
A novel BF(2)-chelated azadipyrromethene-fullerene dyad: synthesis, electrochemistry and photodynamics
(Royal Society of Chemistry, 2012)The synthesis, structure, electrochemistry and photodynamics of a BF2-chelated azadipyrromethene–fullerene dyad are reported in comparison with BF2-chelated azadipyrromethene without fullerene. The attachment of fullerene ... -
Novel fragmentation pathway for CID of (b(n) - 1 + Cat)+ ions from model, metal cationized peptides
(Springer, 2005-08-01)We report a new fragmentation pathway for the CID of (b3 - 1 + Cat)+ product ions derived from the model peptide AXAG, where X = beta-alanine, gamma-aminobutyric acid, epsilon-amino-n-caproic acid, or 4-aminomethylbenzoic ... -
Novel inhibitors of human leukocyte proteinase 3
(2006-05)Chronic obstructive pulmonary disease (COPD) is a multifactorial disorder that is associated with an influx of macrophages, neutrophils and T-lymphocytes to the lungs and the extracellular release of several proteases, ... -
Novel mechanism-based inhibitors of serine proteases
(2005-12)The design and in vitro biochemical evaluation of two novel classes of mechanism-based inhibitors of human leukocyte elastase (HLE) that inactivate the enzyme via an unprecedented enzyme-induced sulfonamide fragmentation ... -
Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one
(Elsevier, 1993-12-15)A series of heterocyclic compounds designed to function as mechanism-based inhibitors of human leukocyte elastase and cathepsin G has been synthesized and their inhibitory activity was investigated. These isothiazolidin-3-one ... -
On-line preconcentration of fluorescent derivatives of catecholamines in cerebrospinal fluid using flow-gated capillary electrophoresis
(Elsevier B.V., 2016-06-10)Flow-gated capillary electrophoresis (CE) coupled with microdialysis has become an important tool for in vivo bioanalytical measurements because it is capable of performing rapid and efficient separations of complex ... -
Online preconcentration of high-salt samples using pressure-assisted field-amplified sample injection in flow-gated capillary electrophoresis
(Wichita State University, 2019-04-26)Capillary electrophoresis (CE) is a valuable separation method; however, its detection sensitivity is often limited by the small sample volumes injected. Different strategies have been developed to enhance the sensitivity, ... -
Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease
(American Chemical Society, 2016-03-10)Human noroviruses are the primary causative agents of acute gastroenteritis and a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or ... -
Oxoporphyrinogens: Electrochemistry, anion binding, and light induced electron transfer studies
(Wichita State University, 2007-12)The research presented in this dissertation deals with the electrochemical, anion binding and photochemical studies of various oxoporphyrinogen systems. The first chapter provides a brief introduction to the material ... -
P(450)/NADPH/O(2)- and P(450)/PhIO-catalyzed N-dealkylations are mechanistically distinct
(American Chemical Society, 2005-02-09)A high-valent iron-oxo species analogous to the compound I of peroxidases has been thought to be the activated oxygen species in P450-catalyzed reactions. Spectroscopic characterization of the catalytically competent ... -
Palladin and regulation of actin crosslinking and dynamics
(Wiley-Blackwell, 2012-08)Palladin is a recently discovered actin-associated protein that appears to be involved in both normal cell migration and invasive cell motility. Recently, we demonstrated that palladin is able to both bind and bundle actin ... -
Palladin Can Compensate for Arp2/3 Complex Defects and Structurally Organizes Actin-Rich Structures Generated during Listeria monocytogenes Infections
(Federation of American Societies for Experimental Biology, 2017-04)The actin cytoskeleton is co-opted by the invasive and motile bacteria Listeria monocytogenes (Listeria) for their entry, intracellular motility and dissemination from one cell to another. Once inside host cells, these ... -
Palladin compensates for branching complex in promoting actin-based motility in listeria
(Wichita State University, 2019-04-26)Palladin is an actin binding protein which has important functions in cell motility both in normal cells during development or in wound healing and in metastatic cancers. The Beck lab has recently shown that palladin ... -
Palladin compensates for the Arp2/3 complex and supports actin structures during Listeria Infections
(American Society For Microbiology, 2018-04-10)Palladin is an important component of motile actin-rich structures and nucleates branched actin filament arrays in vitro. Here we examine the role of palladin during Listeria monocytogenes infections in order to tease out ... -
Palladin Nucleates Actin Assembly and Regulates Cytoskeleton Architecture
(Elsevier Inc., 2015-01-27)The actin scaffold protein palladin regulates both normal cell migration and invasive cell motility, processes that require the coordinated regulation of actin dynamics. Palladin localizes to actin-rich protrusions and has ... -
Palladin nucleates actin assembly and regulates cytoskeleton architecture
(Wichita State University, 2015-05)Palladin is an actin crosslinking protein that uses an immunoglobulin (Ig) domain to bind F-actin. Expression of palladin correlates with increased cell motility in normal cells during development and wound healing, but ... -
Palladin regulates cancer metastasis via actin cytoskeletal remodeling
(Wichita State University, 2016-04-29)The migration of both normal and cancer cells is a complex process that involves dramatic remodeling of the actin cytoskeleton. Currently 90% of cancer deaths result from metastasis, the migration of cells into the ... -
Palladin's Ig4 Mutation: Exploring the link with pancreatic cancer
(Elsevier Inc., 2015-01-27)Palladin is a recently discovered protein that is expressed in human cells and plays a key role in cytoskeletal dynamics by directly binding and bundling filaments of actin. These processes provide an important function ... -
Part I: Characterization of Zn reconstituted Cytochrome B561 Part II: Studies of Catecholamine metabolism in SH-SY5Y and MN9D cells
(Wichita State University, 2009-05)Cytochrome b561, a transmembrane heme protein present in neurotransmitter storage vesicles, shuttles electrons from the cytosolic Asc to the intragranullar matrix to regenerate Asc. Although Cyt b561 has been purified, ...