Browsing Chemistry and Biochemistry by Title
Now showing items 412-431 of 682
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New sandwich complexes of cyano-substituted polypyrazolylborates
(Wichita State University. Graduate School, 2014-04-25)For several years, our research group has been developing cyano-substituted polypyrazolylborate ligands, also called cyanoscorpionate ligands. In previous work, we have demonstrated that cyanoscorpionate ligands have the ... -
New trisubstituted cyanopyrazoles and cyanoscorpionates
(Elsevier B.V., 2017-03-29)New syntheses are reported to give pyrazoles with cyano substituents at the 4-position of the pyrazole ring and ethyl or isopropyl substituents at the 3-position, as well as pyrazoles with cyano substituents at the 4-position ... -
Newly identified C–H⋯O hydrogen bond in histidine
(The Royal Society of Chemistry, 2022-06-19)New Cδ–H⋯O histidine hydrogen bonding interactions in various proteins are identified by neutron diffraction and computationally characterized. Neutron diffraction data shows several H-bond motifs with the Cδ–H moiety in ... -
Ni complexes of N2S ligands with amine/imine and amine/amide donors with relevance to the active site of Ni superoxide dismutase
(Elsevier, 2018-05-01)A series of Ni complexes of the form [Ni((NNS)-S-Im)(RS)] ((NNS)-S-Im = (2-(N-(dimethylaminoethyl)iminomethyl) benzenethiolate; R = phenyl, 4-nitrophenyl, 4-fluorophenyl, 4-chlorophenyl, 4-t-butylphenyl, t-butyl), as well ... -
Nickel amine/imine and amine/amide bisthiolate complexes as models for the active site of nickel superoxide dismutase
(Wichita State University, 2017-07)Nickel Superoxide Dismutase (NiSOD) catalyzes disproportionation of cytotoxic superoxide radical to H2O2 and molecular O2. The mononuclear nickel center in the active site undergoes alternate oxidation and reduction ... -
Nitrile-based carotenoid complexes of Ru (II), Re (I) and Pt (II) metals: Coordination synthesis, electrochemical and photophysical characterization
(Wichita State University, 2009-12)Nitrile-based carotenoid complexes of Ru(II), Re(I) and Pt(II) metal ions have been synthesized. The photolability of two bis-nitrilo ruthenium(II) complexes formulated as [Ru(bpy)₂(L)₂](PF₆)₂, where bpy is 2,2’-bipyridine ... -
Nitro compounds as oxisidizing agents II
(Wichita State University, 1933-08)In this investigation a study was made of the reduction products of the isomers of (1) nitro-benzoic acid; (2) nitro-bromo-benzene; and (3) nitraniline. A study of the effect of temperature and alkalinity on yields and ... -
Non-aqueous titration of hydroxamic acids
(Elsevier, 1966-01-01)Benzohydroxamic acid is titrated with 0.1M tetrabutyl-anunonium hydroxide in nine non-aqueous solvents with three different indicating electrodes. The best results are obtained using dimethylformamide as solvent and ... -
Noncovalent inhibitors of human leukocyte elastase based on the 4-imidazolidinone scaffold
(Elsevier, 2003-11-17)A central problem associated with the design of enzyme inhibitors in general, and serine protease inhibitors in particular, is the identification of templates capable of binding to the active site of an enzyme in a predictable ... -
NOR and AND logic gates based on supramolecular porphyrin-fullerene conjugates
(American Chemical Society, 2010-02-05)Supramolecular porphyrin-fullerene conjugates are employed to build NOR and AND logic gates. A crown ether appended zinc porphyrin and an imidazole or an alkyl ammonium functionalized fullerene are utilized. Quenching of ... -
Novel anti-norovirus therapeutics
(Wichita State University, 2013-05)Noroviruses are the most common cause of acute gastroenteritis, accounting for over 23 million cases annually in the U.S. alone. Norovirus infections constitute an important health problem for which there are no specific ... -
A novel BF(2)-chelated azadipyrromethene-fullerene dyad: synthesis, electrochemistry and photodynamics
(Royal Society of Chemistry, 2012)The synthesis, structure, electrochemistry and photodynamics of a BF2-chelated azadipyrromethene–fullerene dyad are reported in comparison with BF2-chelated azadipyrromethene without fullerene. The attachment of fullerene ... -
Novel fragmentation pathway for CID of (b(n) - 1 + Cat)+ ions from model, metal cationized peptides
(Springer, 2005-08-01)We report a new fragmentation pathway for the CID of (b3 - 1 + Cat)+ product ions derived from the model peptide AXAG, where X = beta-alanine, gamma-aminobutyric acid, epsilon-amino-n-caproic acid, or 4-aminomethylbenzoic ... -
Novel inhibitors of human leukocyte proteinase 3
(2006-05)Chronic obstructive pulmonary disease (COPD) is a multifactorial disorder that is associated with an influx of macrophages, neutrophils and T-lymphocytes to the lungs and the extracellular release of several proteases, ... -
Novel mechanism-based inhibitors of serine proteases
(2005-12)The design and in vitro biochemical evaluation of two novel classes of mechanism-based inhibitors of human leukocyte elastase (HLE) that inactivate the enzyme via an unprecedented enzyme-induced sulfonamide fragmentation ... -
Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one
(Elsevier, 1993-12-15)A series of heterocyclic compounds designed to function as mechanism-based inhibitors of human leukocyte elastase and cathepsin G has been synthesized and their inhibitory activity was investigated. These isothiazolidin-3-one ... -
On-line preconcentration of fluorescent derivatives of catecholamines in cerebrospinal fluid using flow-gated capillary electrophoresis
(Elsevier B.V., 2016-06-10)Flow-gated capillary electrophoresis (CE) coupled with microdialysis has become an important tool for in vivo bioanalytical measurements because it is capable of performing rapid and efficient separations of complex ... -
Online preconcentration of high-salt samples using pressure-assisted field-amplified sample injection in flow-gated capillary electrophoresis
(Wichita State University, 2019-04-26)Capillary electrophoresis (CE) is a valuable separation method; however, its detection sensitivity is often limited by the small sample volumes injected. Different strategies have been developed to enhance the sensitivity, ... -
Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease
(American Chemical Society, 2016-03-10)Human noroviruses are the primary causative agents of acute gastroenteritis and a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or ... -
Oxoporphyrinogens: Electrochemistry, anion binding, and light induced electron transfer studies
(Wichita State University, 2007-12)The research presented in this dissertation deals with the electrochemical, anion binding and photochemical studies of various oxoporphyrinogen systems. The first chapter provides a brief introduction to the material ...