Browsing Chemistry and Biochemistry by Title
Now showing items 392-411 of 675
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Mono- and di-nuclear nickel(II) complexes with mixed N/S-donor ligands: Syntheses, structures and physical properties
(Elsevier, 2012-05-03)Two new Ni(II) complexes are reported with tridentate thiosemicarbazone ligands derived from Schiff-base condensation with phenylthiosemicarbazide. Complex 1, a novel dinuclear Ni(II) complex of a SNS ligand synthesized ... -
MPP+ is only the simplest of a large group of unidentified potent dopaminergic toxins as shown by C. Elegans Parkinson's model studies
(Wichita State University, 2019-12)Although the cause(s) of Parkinson's disease (PD) is not fully understood, it is believed that environmental factors play a major role. The discovery that the synthetic chemical, 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine ... -
MPP+ scaffold containing lipophilic compounds are potent complex I inhibitors and selective dopaminergic toxins
(Wichita State University, 2019-12)Although the exact cause(s) of Parkinson's disease (PD) is not fully understood, it is believed that environmental factors play a major role. The discovery that the synthetic chemical, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ... -
Multi-stage tandem mass spectrometry of metal cationized leucine enkephalin and leucine enkephalin amide
(John Wiley and Sons, 2002-01-01)We have examined the multi-stage collision induced dissociation (CID) of metal cationized leucine enkephalin, leucine enkephalin amide, and the N-acetylated versions of the peptides using ion trap mass spectrometry. In ... -
Multi-triphenylamine-substituted porphyrin-fullerene conjugates as charge stabilizing "antenna-reaction center" mimics
(American Chemical Society, 2007-09-06)A new concept of charge stabilization via delocalization of the pi-cation radical species over the donor macrocycle substituents in a relatively simple donor-acceptor bearing multimodular conjugates is reported. The newly ... -
Myopalladin promotes muscle growth through modulation of the serum response factor pathway
(Wiley Blackwell, 2019-10-24)Background: Myopalladin (MYPN) is a striated muscle-specific, immunoglobulin-containing protein located in the Z-line and I-band of the sarcomere as well as the nucleus. Heterozygous MYPN gene mutations are associated with ... -
Myopalladin's role in cardiac muscle function and disease
(Federation of American Societies for Experimental Biology, 2017-04)Decades of research have provided fundamental insight into the human heart’s structure and function. Yet, most cardiac malformations remain a mystery as scientists and clinicians continue to examine how inherited mutations ... -
Myopalladin's role in cardiac muscle function and disease
(Wichita State University, 2016-04-29)Decades of research have provided fundamental insight into the human heart's structure and function. Yet, most cardiac malformations remain a mystery as scientists and clinicians continue to examine how inherited mutations ... -
N,N,N',N'-tetramethyl-1,4-phenylenediamine: a facile electron donor and chromophoric substrate for dopamine beta-monooxygenase
(Elsevier, 1991-03-29)Dopamine beta-monooxygenase is shown to catalyze the oxidation of N,N,N',N'-tetramethyl-1,4-phenylenediamine (TMPD) to its cation radical in the presence of a regular substrate and molecular oxygen. The enzyme-mediated ... -
N-methyl-4-phenylpyridinium scaffolds containing lipophilic compounds are potent complex i inhibitors and selective dopaminergic toxins
(ACS, 2019-04-01)Although the exact cause or causes of Parkinson's disease (PD) are not fully understood, it is believed that environmental factors play a major role. The discovery that a synthetic chemical, 1-methyl-4-phenyl-1,2,3,6-tet ... -
Near unity photon-to-electron conversion efficiency of photoelectrochemical cells built on cationic water-soluble porphyrins electrostatically decorated onto thin-film nanocrystalline SnO2 surface
(American Chemical Society, 2011-07-01)Thin transparent SnO(2) films have been surface modified with cationic water-soluble porphyrins for photoelectrochemical investigations. Free-base and zinc(II) derivatives of three types of cationic water-soluble porphyrins, ... -
Near-IR excitation transfer and electron transfer in a BF2-chelated dipyrromethane-azadipyrromethane dyad and triad
(WILEY-V C H VERLAG GMBH, 2012-04)A molecular dyad and triad, comprised of a known photosensitizer, BF2-chelated dipyrromethane (BDP), covalently linked to its structural analog and near-IR emitting sensitizer, BF2-chelated tetraarylazadipyrromethane (ADP), ... -
Neutrophil elastase inhibitors
(Informa Healthcare, 2011-03-01)INTRODUCTION: Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health problem. There is currently an urgent and unmet need for the development of small molecule therapeutics capable of blocking and/or ... -
New applications for surfactant based colloidal systems: an experimental and computational approach
(Wichita State University, 2016-07)Surfactants such as cetyltrimethylammonium (CTA+) and cetylpyridinium (CP+) have diverse applications in various biological and industrial processes. In this dissertation, these surfactants with bromide counterions have ... -
A new class of carbamoylating agents based on the cyclosulfamide scaffold
(2006-12)The neutrophil-derived serine proteases human leukocyte elastase (HLE) and proteinase 3 (PR3) have been implicated in various inflammatory diseases such as pulmonary emphysema, chronic bronchitis, asthma, cystic fibrosis, ... -
New insights into the dynamics of zwitterionic micelles and their hydration waters by gigahertz-to-terahertz dielectric spectroscopy
(American Chemical Society, 2016-10-20)Gigahertz-to-terahertz spectroscopy of macromolecules in aqueous environments provides an important approach for identifying their global and transient molecular structures, as well as directly assessing hydrogen-bonding. ... -
New sandwich complexes of cyano-substituted polypyrazolylborates
(Wichita State University. Graduate School, 2014-04-25)For several years, our research group has been developing cyano-substituted polypyrazolylborate ligands, also called cyanoscorpionate ligands. In previous work, we have demonstrated that cyanoscorpionate ligands have the ... -
New trisubstituted cyanopyrazoles and cyanoscorpionates
(Elsevier B.V., 2017-03-29)New syntheses are reported to give pyrazoles with cyano substituents at the 4-position of the pyrazole ring and ethyl or isopropyl substituents at the 3-position, as well as pyrazoles with cyano substituents at the 4-position ... -
Newly identified C–H⋯O hydrogen bond in histidine
(The Royal Society of Chemistry, 2022-06-19)New Cδ–H⋯O histidine hydrogen bonding interactions in various proteins are identified by neutron diffraction and computationally characterized. Neutron diffraction data shows several H-bond motifs with the Cδ–H moiety in ... -
Ni complexes of N2S ligands with amine/imine and amine/amide donors with relevance to the active site of Ni superoxide dismutase
(Elsevier, 2018-05-01)A series of Ni complexes of the form [Ni((NNS)-S-Im)(RS)] ((NNS)-S-Im = (2-(N-(dimethylaminoethyl)iminomethyl) benzenethiolate; R = phenyl, 4-nitrophenyl, 4-fluorophenyl, 4-chlorophenyl, 4-t-butylphenyl, t-butyl), as well ...