Browsing Chemistry and Biochemistry by Title
Now showing items 352-371 of 675
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Localization of post-translational modifications in peptide mixtures via high-resolution differential ion mobility separations followed by electron transfer dissociation
(Springer International Publishing, 2016-12)Precise localization of post-translational modifications (PTMs) on proteins and peptides is an outstanding challenge in proteomics. While electron transfer dissociation (ETD) has dramatically advanced PTM analyses, mixtures ... -
Long-range stabilization of anthrax protective antigen upon binding to CMG2
(American Chemical Society, 2014-09-30)Protective antigen (PA) mediates entry of edema factor (EF) and lethal factor (LF) into the cytoplasmic space of the cells through the formation of a membrane-spanning pore. To do this, PA must initially bind to a host ... -
Loss of mercaptan sulfur in normal heptane by the use of caustic soda, refractive indices, densities, and viscosities of the lighter mercaptans
(Wichita State University, 1932-05) -
Low-field differential ion mobility spectrometry of dipole-aligned macromolecules
(American Chemical Society, 2020-09-04)Ion mobility spectrometry (IMS) with mass spectrometry has grown into a powerful approach to simplify complex mixtures, disentangle isomers, and elucidate their geometries. Two established branches are linear IMS based on ... -
LRP6 holds the key to the entry of anthrax toxin
(Elsevier, 2006-03-24)In this issue of Cell, it is demonstrated that the low-density lipoprotein receptor-related protein 6 (LRP6) promotes endocytosis of the anthrax toxin into cells. LRP6 acts as a coreceptor with either TEM8 or CMG2, the two ... -
Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses
(United States Patent and Trademark Office, 2016-04-12)Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ... -
Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirus
(Elsevier, 2013-05-16)The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective ... -
Macrocyclic inhibitors of Norovirus 3CL protease
(Wichita State University, 2016-07)Noroviruses are the leading cause of foodborne illness in the U.S., accounting for >21 million infections per year and resulting in >70000 hospitalizations and nearly 800 deaths. Noroviruses are the primary cause of sporadic ... -
Magnetic topological semimetal phase with electronic correlation enhancement in SmSbTe
(Wiley, 2021-08-24)The ZrSiS family of compounds hosts various exotic quantum phenomena due to the presence of both topological nonsymmorphic Dirac fermions and nodal-line fermions. In this material family, the LnSbTe (Ln = lanthanide) ... -
Maleated soybean oil derivatives as versatile reactive diluents: Synthesis, characterization, and evaluation
(John Wiley and Sons Inc, 2021-11-02)Four maleated soybean oil (SBO) derivatives were synthesized and used as bio-based reactive diluents (RDs) for alkyd coating systems. The RDs were prepared in a two-step fashion: (a) Maleation of SBO with maleic anhydride ... -
Mammalian and viral protease inhibitors
(Wichita State University, 2010-05)Chronic Obstructive Pulmonary Disease (COPD) is currently the fourth leading cause of death in the US. COPD is a multi-factorial disorder characterized by an oxidant/antioxidant imbalance, inflammation, a protease/antiprotease ... -
Mapping the triplet potential energy surface of 1-methyl-8-nitronaphthalene
(American Chemical Society, 2005-07-22)Spin-unrestricted calculations and time-dependent DFT were used to characterize structure and reactivity of 1-methyl-8-nitronaphthalene (1) in the triplet state. Four hybrid models (B3LYP, PBE0, MPW1K, BHLYP) with significantly ... -
McLafferty rearrangement of peptides and substituent effects on peptide fragmentation: Theoretical and experimental investigation
(Wichita State University, 2009-12)The research presented here details two studies that utilized theoretical analysis and experimentation to further the understading of peptide fragmentation. The first study was the McLafferty rearrangement, which involves ... -
McLafferty-type rearrangement in the collision-induced dissociation of Li+, Na+ and Ag+ cationized esters of N-acetylated peptides
(John Wiley and Sons, 2003-01-01)In this study we investigated the multi-stage collision-induced dissociation (CID) of N-terminally acetylated di-, tri- and tetrapeptides in the form of C-terminal ethyl, n-propyl, isopropyl, n-butyl and tert-butyl esters ... -
Mechanism-based inactivation of humam neutrophil elastase
(Wichita State University, 2008-12)Chronic obstructive pulmonary disease (COPD) is a major health problem that affects 16 million people in the US, and is currently the fourth most common cause of death. Although the pathogenesis of COPD is poorly understood, ... -
Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process
(Elsevier, 2004-09-01)We describe herein the design and in vitro biochemical evaluation of a novel class of mechanism-based inhibitors of human leukocyte elastase (HLE) that inactivate the enzyme via an unprecedented enzyme-induced sulfonamide ... -
Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils
(Elsevier, 1994-11-29)A series of dihydrouracil derivatives has been synthesized and investigated for their in vitro inhibitory activity toward human leukocyte elastase (HLE) and cathepsin G (Cath G). Alkyl [sulfonyl(oxy)] uracils 1-2 were found ... -
Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding
(Elsevier, 2009-05-15)A series of mechanism-based inhibitors designed to interact with the S' subsites of serine proteases was synthesized and their inhibitory activity toward the closely-related serine proteases human neutrophil elastase (HNE) ... -
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement
(Elsevier, 1993-08-16)Neutrophil-derived mediators such as, for example, the serine proteinase elastase, cathepsin G and proteinase 3, play a critical role in inflammatory lung disease. This report describes the design, synthesis and in vitro ... -
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain
(Nature Publishing Group, 2016-02-16)Amphetamines elevate extracellular dopamine, but the underlying mechanisms remain uncertain. Here we show in rodents that acute pharmacological inhibition of the vesicular monoamine transporter (VMAT) blocks amphetamine-induced ...