Browsing Chemistry and Biochemistry by Title
Now showing items 304-323 of 691
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Influence of amino acid side chains on apparent selective opening of cyclic b5 ions
(Springer, 2010-06-01)In this study, the possible influence of acidic, basic, and amide side chains on the opening of a putative macrocyclic b ion (b(5)(+)) intermediate was investigated. Collision induced dissociation (CID) of b(5) ions was ... -
The influence of cation and “alternative” amino acids on the fragmentation pathways of metal cationized and protonated peptides
(Wichita State University, 2008-05)Tandem mass spectrometry and collision-induced dissociation (CID) are the “workhorse” methods for protein identification in proteomics investigations. Recent studies have demonstrated significant differences in the CID ... -
Influence of size on apparent scrambling of sequence during CID of b-type ions
(Springer, 2009-11-01)We investigated the influence of peptide size on the apparent loss of sequence during collision-induced dissociation (CID) of b ions using a group of peptides containing from between 4 and 10 residues. Although scrambling ... -
Infrared multiple photon dissociation spectroscopy of group I and group II metal complexes with Boc-hydroxylamine
(WILEY-BLACKWELL, 2013-08-30)RATIONALE Hydroxamates are essential growth factors for some microbes, acting primarily as siderophores that solubilize iron for transport into a cell. Here we determined the intrinsic structure of 1:1 complexes between ... -
Infrared multiple photon dissociation spectroscopy of sodium and potassium chlorate anions
(John Wiley and Sons, 2010-01-01)The structures of gas-phase, metal chlorate anions with the formula [M(ClO(3))(2)](-), M = Na and K, were determined using tandem mass spectrometry and infrared multiple photon dissociation (IRMPD) spectroscopy. Structural ... -
Infrared multiple-photon dissociation spectroscopy of group II metal complexes with salicylate
(John Wiley and Sons, 2011-07-15)Ion trap tandem mass spectrometry with collision-induced dissociation, and the combination of infrared multiple-photon dissociation (IRMPD) spectroscopy and density functional theory (DFT) calculations, were used to ... -
The inherent high vulnerability of dopaminergic neurons toward mitochondrial toxins may contribute to the etiology of Parkinsons disease
(Medknow, 2016-03-16)Although the exact mechanism(s) of the degeneration of dopaminergic neurons in Parkinson's disease (PD) is not well understood, mitochondrial dysfunction is proposed to play a central role. This proposal is strongly ... -
Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives
(Elsevier, 2012-02)Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed ... -
Inhibition of human leukocyte elastase by derivatives of N-hydroxysuccinimide. A structure-activity-relationship study
(American Chemical Society, 1989-07-01)A series of compounds derived from 3-alkyl-N-hydroxysuccinimide have been synthesized and their inhibitory activity toward human leukocyte elastase has been investigated. Compounds having an isobutyl or isopropyl group at ... -
Inhibition of human leukocyte elastase by phosphate esters of N-hydroxysuccinimide and its derivatives: direct observation of a phosphorylated enzyme by 31P nuclear magnetic resonance spectroscopy
(American Chemical Society, 1991-04-30)A series of phosphate esters derived from N-hydroxysuccinimide and 3-alkyl-N-hydroxysuccinimide have been synthesized and found to be potent time-dependent irreversible inhibitors of human leukocyte elastase (HLE). The ... -
Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032)
(Elsevier, 1997-04-28)The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex ... -
Inhibition of human tryptase by 1, 2, 5 - thiadiazolidin-3-one 1, 1 dioxide-based heterocyclic sulfides
(Wichita State University. Graduate School., 2005-04-22) -
Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors
(PERGAMON-ELSEVIER SCIENCE LTD, 2013-01)Noroviruses are the most common cause of acute viral gastroenteritis, accounting for >21 million cases annually in the US alone. Norovirus infections constitute an important health problem for which there are no specific ... -
Inhibition of noroviruses by piperazine derivatives
(Elsevier, 2012-01)There is currently an unmet need for the development of small-molecule therapeutics for norovirus infection. The piperazine scaffold, a privileged structure embodied in many pharmacological agents, was used to synthesize ... -
Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents
(Elsevier, 2008-07-15)A new class of carbamylating agents based on the cyclosulfamide scaffold is reported. These compounds were found to be efficient time-dependent inhibitors of human neutrophil elastase (HNE). Exploitation of the three sites ... -
Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
(Elsevier, 2001-06-01)A challenge associated with drug design is the development of selective inhibitors of proteases (serine or cysteine) that exhibit the same primary substrate specificity, that is, show a preference for the same P(1) residue. ... -
Inhibitors of Dengue Virus and West Nile Virus proteases based on the aminobenzamide scaffold
(Elsevier, 2012-05-10)Dengue and West Nile viruses (WNV) are mosquito-borne members of flaviviruses that cause significant morbidity and mortality. There is no approved vaccine or antiviral drugs for human use to date. In this study, a series ... -
Inhibitors of human leukocyte proteinase-3
(American Chemical Society, 1990-04-01) -
Inhibitors of human neutrophil cathepsin G: structural and biochemical studies
(Elsevier, 1992-04-01)The interaction of a series of sulfonate and phosphate esters derived from N-hydroxysuccinimide with human leukocyte cathepsin G was investigated. The synthesized compounds were found to be time-dependent inhibitors of the ... -
Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold
(Elsevier, 2010-09-01)A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible ...