Browsing Chemistry and Biochemistry by Title
Now showing items 21-40 of 630
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Addition of H2O and O2 to acetone and dimethylsulfoxide ligated uranyl(V) dioxocations
(American Chemical Society, 2009-03-19)Gas-phase complexes of the formula [UO2(lig)]+ (lig = acetone (aco) or dimethylsulfoxide (dmso)) were generated by electrospray ionization (ESI) and studied by tandem ion-trap mass spectrometry to determine the general ... -
Advances in structure determination by cryo-EM to unravel membrane-spanning pore formation
(John Wiley and Sons, 2018-08-20)The beta pore-forming proteins (-PFPs) are a large class of polypeptides that are produced by all Kingdoms of life to contribute to their species' own survival. Pore assembly is a sophisticated multi-step process that ... -
Advances in the use of cyclodextrins as chiral selectors in capillary electrokinetic chromatography: fundamentals and applications
(Springer Berlin Heidelberg, 2016-11)Capillary electrokinetic chromatography is generally recognized as a versatile and robust capillary electromigration technique for the separation of enantiomers. In this mode, one or more chiral selectors are added to the ... -
Affinity chromatography of glucose dehydrogenase
(Springer, 1988-01-15)Porcine liver beta-D-glucose dehydrogenase, a multi-functional protein, has been purified to apparent homogeneity. The enzyme has been separated from the endoplasmic reticulum using Triton X-114 and further purified using ... -
Aggregation models of potential cyclical trimethylsulfonium dicyanamide ionic liquid clusters
(American Chemical Society, 2009-02-19)Raman and infrared spectra of trimethylsulfonium dicyanamide [(CH(3))(3)SN(CN)(2)] are reported and accurately reproduced by DFT methods (B3LYP and B3PW91), MP2, and MP3, and to a lesser extent by the RHF method. The ... -
Altered acetylcholinesterase activity (AChE) and maze performance of developing rats (Rattus norvegicus) following mesencephalic electrical brain stimulation
(Springer-Verlag, 1977-11-17)Cortical arousal was altered by electrical brain stimulation (EBS) to the mesencephalic ascending reticular formation beginning at 27 days of age and administered 2 h/day for either 14 or 28 days. Subjects receiving brain ... -
Alternate injections coupled with flow-gated capillary electrophoresis for rapid and accurate quantitative analysis of urine samples
(Elsevier B.V., 2017-07-25)Capillary electrophoresis (CE) is a powerful separation technique with advantages over HPLC in terms of separation efficiency, speed, and cost. However, CE suffers in poor reproducibility in quantitative chemical analysis, ... -
Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets
(American Society of Microbiology, 2012-09)We have identified four synthetic compounds (DFD-VI-15, BD-I-186, DFD-V-49, and DFD-V-66) from an amino acid-derived 1,2-benzisothiazolinone (BZT) scaffold that have reasonable MIC50 values against a panel of fungal ... -
Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3
(Elsevier, 1996-08-15)Amino acid-derived phthalimide and saccharin derivatives have been investigated for their inhibitory activity toward the serine proteinases human leukocyte elastase, cathepsin G, and proteinase 3. The saccharin derivatives ... -
An investigation of various methods for the volumetric determination of antimony
(Wichita State University, 1932-05)This invesigation was prompted by the fact that a local industrial plant was unable to make satisfactory determinations of the antimony content of the low melting point alloys used in their products. The problem presented ... -
Analysis of 1-methyl-4-phenylpyridinium derivatives in caenorhabtis elegans
(Wichita State University, 2018-04-27)Parkinson's disease (PD) is a neurodegenerative disease that affects more than 10 million people worldwide and costs 25 billion dollars in the United States alone. Despite its notoriety, the etiology of PD not fully ... -
Analysis of enzyme and solvent dynamics of Candida antarctica lipase B in non-aqueous solvents using molecular dynamics simulations
(American Chemical Society, 2014-08-10)Solvents play a major role in changing biomolecule structure, dynamics and functions. The main objective of this project is to use molecular dynamics simulations to shed light on enzyme-solvent interactions between Candida ... -
Anion-complexation-induced stabilization of charge separation
(American Chemical Society, 2009-11-11)A supramolecular oligochromophoric system possessing exclusive binding sites for both a guest electron acceptor and an anionic cofactor species is developed, and anion-binding-induced stabilization of the charge-separated ... -
Anthrax toxin protective antigenuInsights into molecular switching from prepore to pore
(Cambridge University Press, 2012-01)The protective antigen is a key component of the anthrax toxin, as it allows entry of the enzymatic components edema factor and lethal factor into the host cell, through the formation of a membrane spanning pore. This event ... -
Anti-norovirus therapeutics: a patent review (2010-2015)
(Taylor & Francis Group, 2016-03-03)Introduction: Human noroviruses are the primary causative agents of acute gastroenteritis and are a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the ... -
Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives
(Elsevier, 2011-10-01)A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the ... -
Antifungal drug discovery: the process and outcomes
(Future Medicine Ltd, 2014-06)New data suggest that the global incidence of several types of fungal diseases have traditionally been under- documented. Of these, mortality caused by invasive fungal infections remains disturbingly high, equal to or ... -
Antiviral drug discovery: norovirus proteases and development of inhibitors
(MDPI AG, Basel, Switzerland, 2019-02-25)Proteases are a major enzyme group playing important roles in a wide variety of biological processes in life forms ranging from viruses to mammalians. The aberrant activity of proteases can lead to various diseases; ... -
Apparent inhibition by arginine of macrocyclic b ion formation from singly charged protonated peptides
(Springer, 2010-08-01)There is now strong evidence for the existence of macrocyclic isomers of b(n)(+) ions, the formation and subsequent opening of which can lead to loss of sequence information from protonated peptides in multiple-stage tandem ... -
Application of photoexcited states of Re (I) metal complexes to solar energy conversion
(American Chemical Society, 2014-03-16)Dye sensitized solar cells (Grätzel Cell) have attracted significant attention as promising next generation photovoltaic devices. In a photovoltaic cell, the dye sensitizers anchored to mesoporous thin films made of the ...