Browsing Chemistry and Biochemistry by Title
Now showing items 189-208 of 675
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Does palladin bind to monomeric actin?
(Wichita State University, 2020-05-01)Every cell has a cytoskeleton that in eukaryotes contains microfilaments composed of actin subunits. Actin is one of the most abundant proteins in the cell and is crucial for vital cellular processes such as cell motility, ... -
Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH
(John Wiley and Sons, 2009-11)Domain 4 of the anthrax protective antigen (PA) plays a key role in cellular receptor recognition as well as in pH-dependent pore formation. We present here the 1.95 A crystal structure of domain 4, which adopts a fold ... -
Dopaminergic cell toxicity of N-substituted derivatives of Parkinsonian toxin 1-Methyl-4-phenylpyridinium (MPP+)
(Wichita State University, 2017-04-28)Parkinson's disease (PD) is a neurodegenerative disease whose etiology is unknown but genetics, environmental factors, and mitochondrial mutations may play a role. 1-Methyl-4-phenylpyridinium (MPP+) is a model for PD since ... -
Dopaminergic Toxicity of 1-methyl-4-phenylpyridinium (MPP+): Models for Parkinson's disease (PD) -- restricted access to full text
(Wichita State University. Graduate School, 2011-05-04)1-methyl-4-phenylpyridinium (MPP+) selectively destroys dopaminergic neurons and induces the symptoms similar to Parkinson's disease. The dopaminergic toxicity of MPP+ could be due to dopamine transporter (DAT) uptake and ... -
Double-branch capillary electrophoresis by using microfluidic switch for alternate injections
(Wichita State University, 2016-04-29)Capillary electrophoresis (CE) is an analytical tool which has gained great interests during the past decade. The main attractions of CE are its fast, high-throughput and highly efficient separations. However, conventional ... -
Dual function inhibitors of relevance to chronic obstructive pulmonary disease
(Elsevier, 2011-05-15)The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are ... -
Dye sensitized solar photoelectrochemical cells
(American Chemical Society, 2013-09-08)The use of dye sensitized solar photoelectrochemical cells offers an alternative source of energy using visible light from the sun. A typical cell contains a photoanode, a platinum cathode and the I3-/I- electrolyte. The ... -
Dynamic Preference for NADP/H Cofactor Binding/Release in E. coli YqhD Oxidoreductase
(MDPI, 2021-01)YqhD, an E. coli alcohol/aldehyde oxidoreductase, is an enzyme able to produce valuable bio-renewable fuels and fine chemicals from a broad range of starting materials. Herein, we report the first computational solution-phase ... -
Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation
(American Chemical Society, 2007-12-25)The action of anthrax toxin relies in part upon the ability of the protective antigen (PA) moiety to form a heptameric pore in the endosomal membrane, providing a portal for entry of the enzymic moieties of the toxin into ... -
Effect of axial ligation or pi-pi-type interactions on photochemical charge stabilization in "two-point" bound supramolecular porphyrin-fullerene conjugates
(John Wiley and Sons, 2005-07-18)Two types of structurally well-defined, self-assembled zinc porphyrin-fullerene conjugates were formed by "two-point" binding strategies to probe the effect of axial ligation or pi-pi-type interactions on the photochemical ... -
Effect of the receptor CMG2 on stability changes in Domain IV of anthrax toxin protective antigen in comparison to the full-length protein
(Wichita State University, 2016-04-29)The anthrax protective antigen is an 83 kDa protein secreted by Bacillus anthracis, and is required for entry of the edema factor and lethal factor, that leads to Anthrax. PA bound to Capillary Morphogenesis Receptor (CMG2) ... -
Effects of nanosilica filler on the thermal and mechanical properties of an epoxy/amine resin system
(Wichita State University, 2011-12)The cure kinetics of an epoxy resin with surface modified silica filler (Nanopox F 400 resin) and without silica filler (DGEBA resin), cured with an amine curing agent, DDS at an N-H/epoxy molar ratio of 1.1:1 was studied ... -
Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase
(Elsevier, 2010-09-15)A structurally-diverse series of carboxylate derivatives based on the 1,2,5-thiadiazolidin-one 1,1 dioxide scaffold were synthesized and used to probe the S' subsites of human neutrophil elastase (HNE) and neutrophil ... -
Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis
(SAGE, 2018-04)Objectives. The safety and efficacy of the 3C-like protease inhibitor GC376 was tested on a cohort of client-owned cats with various forms of feline infectious peritonitis (FIP). Methods. Twenty cats from 3.3-82 months ... -
Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives
(American Chemical Society, 1993-10-15)A series of saccharin derivatives I has been synthesized and evaluated for their inhibitory activity toward human leukocyte elastase and cathepsin G. Most of the compounds were found to be efficient and time-dependent ... -
Electrochemical, spectral, and computational studies of metalloporphyrin dimers formed by cation complexation of crown ether cavities
(American Chemical Society, 2004-11-01)The effect on the electrochemical oxidation and reduction potentials of 5,10,15,20-tetrakis(benzo-15-crown-5)porphyrin (TCP) and its metal derivatives (MTCP; M = Mg(II), VO(IV), Co(II), Ni(II), Cu(II), Zn(II), Pd(II), ... -
Electrochemistry and spectral characterization of oxidized and reduced (TPPBr(x)())FeCl where TPPBr(x)() is the dianion of beta-brominated-pyrrole tetraphenylporphyrin and x varies from 0 to 8
(American Chemical Society, 1996-09-11)The electrochemistry and spectroelectrochemistry of (TPPBr(x)())FeCl (TPPBr(x)() is the dianion of beta-brominated-pyrrole tetraphenylporphyrin and x = 0-8) were examined in PhCN containing tetra-n-butylammonium perchlorate ... -
Electron transfer dissociation of dipositive uranyl and plutonyl coordination complexes
(John Wiley and Sons, 2011-12)Reported here is a comparison of electron transfer dissociation (ETD) and collision-induced dissociation (CID) of solvent-coordinated dipositive uranyl and plutonyl ions generated by electrospray ionization. Fundamental ... -
Electron transfer in porphyrin-fullerene dyads
(Wichita State University. Graduate School., 2005-04-22)