Browsing Chemistry and Biochemistry by Title
Now showing items 150-169 of 680
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Design and physico-chemical studies of "two-point" bound supramolecular porphyrin-fullerene conjugates formed by cation-crown ether complexation and axial co-ordination or π-π interactions
(Wichita State University. Graduate School., 2006-04-28) -
Design and studies of a self-assembled cofacial zinc phthalocyanine dimer complexed with fullerene(s)
(Wichita State University. Graduate School., 2008-04-25)Biomimetic bacterial photosynthetic reaction center complexes have been constructed using welldefined self-assembled supramolecular approaches. The “special pair” donor, a cofacial phthalocyanine dimer, was formed via ... -
Design and studies of azadipyrromethene appended donor-acceptor conjugates
(Wichita State University, 2011-07)The research work presented in this thesis is comprised of syntheses, characterization, electrochemical and photophysical studies of aza-BODIPY appended donor-acceptor conjugates. The first chapter delivers an introduction ... -
Design and studies of photo-induced electron transfer in ‘Pacman’ type porphyrin-fullerene conjugates
(Wichita State University. Graduate School., 2007-04-27)The design of donor-acceptor systems and the study of their photo-induced electron transfer processes are of current interest in artificial photosynthesis and solar energy conversion. Among donor-acceptor conjugates, ... -
Design and studies on supramolecular ferrocene-porphyrin-fullerene constructs for generating long-lived charge separated states
(American Chemical Society, 2006-12-21)Supramolecular ferrocene-porphyrin-fullerene constructs, in which covalently linked ferrocene-porphyrin-crown ether compounds were self-assembled with alkylammonium cation functionalized fullerenes, have been designed to ... -
Design and synthesis of inhibitors of noroviruses by scaffold hopping
(Elsevier, 2011-10-01)A scaffold hopping strategy was employed to identify new chemotypes that inhibit noroviruses. The replacement of the cyclosulfamide scaffold by an array of heterocyclic scaffolds lead to the identification of additional ... -
Design, syntheses, and studies of supramolecular porphyrin-fullerene conjugates, using bis-18-crown-6 appended porphyrins and pyridine or alkyl ammonium functionalized fullerenes
(American Chemical Society, 2006-03-30)Photoinduced electron-transfer processes in cis and trans functionalized bis-18-crown-6 porphyrin self-assembled with fullerene functionalized with pyridine or alkylammonium cation entities are reported. The structural ... -
Design, synthesis and biological evaluation of small molecules with potential antibacterial and antiviral activity
(Wichita State University, 2022-05)In recent years, the ongoing explosion of antibiotic-resistance and viral infections has posed a major threat to global public health and called for the development of new therapeutics. Here, a set of novel compounds are ... -
Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3
(Elsevier, 1995-04-01)Structure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives. -
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases
(PERGAMON-ELSEVIER SCIENCE LTD, 2013-01)1,2-Benzisothiazol-3(2H)-ones and 1,3,4-oxadiazoles individually have recently attracted considerable interest in drug discovery, including as antibacterial and antifungal agents. In this study, a series of functionalized ... -
Design, synthesis and study of photophysical properties of Re(I) and Ru(II) metal center organometallic complexes as dyes for harvesting sunlight.
(Wichita State University, 2018-07)Due to fascinating physical and photophysical properties, the Re(I) and Ru(II) metal complexes coordinated with small organic molecules, such as 2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyrazine derivatives, are very ... -
Design, synthesis, and biochemical evaluation of novel inhibitors of Norwalk virus 3CL protease
(Wichita State University, 2014-05)Noroviruses are the most common cause of acute gastroenteritis in the US and worldwide, accounting for ~21 million cases of gastroenteritis annually in the US alone. Noroviruses are very stable in the environment and ... -
Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors
(Elsevier Ltd, 2013-12-01)A class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array ... -
Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease
(Elsevier B.V., 2017-02-15)Norovirus infections have a major impact on public health worldwide, yet there is a current dearth of norovirus-specific therapeutics and prophylactics. This report describes the discovery of a novel class of macrocyclic ... -
Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease
(Elsevier, 2011-09-15)The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The ... -
Design, synthesis, and evaluation of novel prodrugs of transition state inhibitors of norovirus 3CL protease
(American Chemical Society, 2017-07-03)Ester and carbamate prodrugs of aldehyde bisulfite adduct inhibitors were synthesized in order to improve their pharmacokinetic and pharmacodynamic properties. The inhibitory activity of the compounds against norovirus ... -
Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold
(Elsevier, 2004-02-01)The design of novel functionalized templates capable of binding to the active site of serine proteases could potentially lead to the development of potent and highly selective non-covalent inhibitors of these enzymes. Using ... -
Design, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds
(American Chemical Society, 2010-11-08)The 1-oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) ... -
Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners
(Elsevier, 1996-09-01)The inhibitory activity toward human leukocyte elastase (HLE), cathepsin G (Cat G), and proteinase 3 (PR 3) of a series of saccharin derivatives having a sulfinate leaving group was investigated. The results of this study ... -
Design, synthesis, and photophysical properties of Re(I) tricarbonyl 1,10-phenanthroline complexes
(Elsevier, 2021-01-05)A series of [Re(5-R-phen)(CO)3(X)]0/+, where phen = 1,10-phenanthroline, R = H, CN, COOH, COONH2, and X = Cl or pyridine, was prepared and characterized by elemental analyses, NMR, Vis/UV, emission and cyclic voltammetry. ...