Browsing Chemistry and Biochemistry by Title
Now showing items 409-428 of 691
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N,N,N',N'-tetramethyl-1,4-phenylenediamine: a facile electron donor and chromophoric substrate for dopamine beta-monooxygenase
(Elsevier, 1991-03-29)Dopamine beta-monooxygenase is shown to catalyze the oxidation of N,N,N',N'-tetramethyl-1,4-phenylenediamine (TMPD) to its cation radical in the presence of a regular substrate and molecular oxygen. The enzyme-mediated ... -
N-methyl-4-phenylpyridinium scaffolds containing lipophilic compounds are potent complex i inhibitors and selective dopaminergic toxins
(ACS, 2019-04-01)Although the exact cause or causes of Parkinson's disease (PD) are not fully understood, it is believed that environmental factors play a major role. The discovery that a synthetic chemical, 1-methyl-4-phenyl-1,2,3,6-tet ... -
Near unity photon-to-electron conversion efficiency of photoelectrochemical cells built on cationic water-soluble porphyrins electrostatically decorated onto thin-film nanocrystalline SnO2 surface
(American Chemical Society, 2011-07-01)Thin transparent SnO(2) films have been surface modified with cationic water-soluble porphyrins for photoelectrochemical investigations. Free-base and zinc(II) derivatives of three types of cationic water-soluble porphyrins, ... -
Near-IR excitation transfer and electron transfer in a BF2-chelated dipyrromethane-azadipyrromethane dyad and triad
(WILEY-V C H VERLAG GMBH, 2012-04)A molecular dyad and triad, comprised of a known photosensitizer, BF2-chelated dipyrromethane (BDP), covalently linked to its structural analog and near-IR emitting sensitizer, BF2-chelated tetraarylazadipyrromethane (ADP), ... -
Neutrophil elastase inhibitors
(Informa Healthcare, 2011-03-01)INTRODUCTION: Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health problem. There is currently an urgent and unmet need for the development of small molecule therapeutics capable of blocking and/or ... -
New applications for surfactant based colloidal systems: an experimental and computational approach
(Wichita State University, 2016-07)Surfactants such as cetyltrimethylammonium (CTA+) and cetylpyridinium (CP+) have diverse applications in various biological and industrial processes. In this dissertation, these surfactants with bromide counterions have ... -
A new class of carbamoylating agents based on the cyclosulfamide scaffold
(2006-12)The neutrophil-derived serine proteases human leukocyte elastase (HLE) and proteinase 3 (PR3) have been implicated in various inflammatory diseases such as pulmonary emphysema, chronic bronchitis, asthma, cystic fibrosis, ... -
New insights into the dynamics of zwitterionic micelles and their hydration waters by gigahertz-to-terahertz dielectric spectroscopy
(American Chemical Society, 2016-10-20)Gigahertz-to-terahertz spectroscopy of macromolecules in aqueous environments provides an important approach for identifying their global and transient molecular structures, as well as directly assessing hydrogen-bonding. ... -
New sandwich complexes of cyano-substituted polypyrazolylborates
(Wichita State University. Graduate School, 2014-04-25)For several years, our research group has been developing cyano-substituted polypyrazolylborate ligands, also called cyanoscorpionate ligands. In previous work, we have demonstrated that cyanoscorpionate ligands have the ... -
New trisubstituted cyanopyrazoles and cyanoscorpionates
(Elsevier B.V., 2017-03-29)New syntheses are reported to give pyrazoles with cyano substituents at the 4-position of the pyrazole ring and ethyl or isopropyl substituents at the 3-position, as well as pyrazoles with cyano substituents at the 4-position ... -
Newly identified C–H⋯O hydrogen bond in histidine
(The Royal Society of Chemistry, 2022-06-19)New Cδ–H⋯O histidine hydrogen bonding interactions in various proteins are identified by neutron diffraction and computationally characterized. Neutron diffraction data shows several H-bond motifs with the Cδ–H moiety in ... -
Ni complexes of N2S ligands with amine/imine and amine/amide donors with relevance to the active site of Ni superoxide dismutase
(Elsevier, 2018-05-01)A series of Ni complexes of the form [Ni((NNS)-S-Im)(RS)] ((NNS)-S-Im = (2-(N-(dimethylaminoethyl)iminomethyl) benzenethiolate; R = phenyl, 4-nitrophenyl, 4-fluorophenyl, 4-chlorophenyl, 4-t-butylphenyl, t-butyl), as well ... -
Nickel amine/imine and amine/amide bisthiolate complexes as models for the active site of nickel superoxide dismutase
(Wichita State University, 2017-07)Nickel Superoxide Dismutase (NiSOD) catalyzes disproportionation of cytotoxic superoxide radical to H2O2 and molecular O2. The mononuclear nickel center in the active site undergoes alternate oxidation and reduction ... -
Nitrile-based carotenoid complexes of Ru (II), Re (I) and Pt (II) metals: Coordination synthesis, electrochemical and photophysical characterization
(Wichita State University, 2009-12)Nitrile-based carotenoid complexes of Ru(II), Re(I) and Pt(II) metal ions have been synthesized. The photolability of two bis-nitrilo ruthenium(II) complexes formulated as [Ru(bpy)₂(L)₂](PF₆)₂, where bpy is 2,2’-bipyridine ... -
Nitro compounds as oxisidizing agents II
(Wichita State University, 1933-08)In this investigation a study was made of the reduction products of the isomers of (1) nitro-benzoic acid; (2) nitro-bromo-benzene; and (3) nitraniline. A study of the effect of temperature and alkalinity on yields and ... -
Non-aqueous titration of hydroxamic acids
(Elsevier, 1966-01-01)Benzohydroxamic acid is titrated with 0.1M tetrabutyl-anunonium hydroxide in nine non-aqueous solvents with three different indicating electrodes. The best results are obtained using dimethylformamide as solvent and ... -
Noncovalent inhibitors of human leukocyte elastase based on the 4-imidazolidinone scaffold
(Elsevier, 2003-11-17)A central problem associated with the design of enzyme inhibitors in general, and serine protease inhibitors in particular, is the identification of templates capable of binding to the active site of an enzyme in a predictable ... -
NOR and AND logic gates based on supramolecular porphyrin-fullerene conjugates
(American Chemical Society, 2010-02-05)Supramolecular porphyrin-fullerene conjugates are employed to build NOR and AND logic gates. A crown ether appended zinc porphyrin and an imidazole or an alkyl ammonium functionalized fullerene are utilized. Quenching of ... -
Novel anti-norovirus therapeutics
(Wichita State University, 2013-05)Noroviruses are the most common cause of acute gastroenteritis, accounting for over 23 million cases annually in the U.S. alone. Norovirus infections constitute an important health problem for which there are no specific ... -
A novel BF(2)-chelated azadipyrromethene-fullerene dyad: synthesis, electrochemistry and photodynamics
(Royal Society of Chemistry, 2012)The synthesis, structure, electrochemistry and photodynamics of a BF2-chelated azadipyrromethene–fullerene dyad are reported in comparison with BF2-chelated azadipyrromethene without fullerene. The attachment of fullerene ...