Browsing Chemistry and Biochemistry by Title
Now showing items 345-364 of 682
-
Kinetic evidence for channeling of dopamine between monoamine transporter and membranous dopamine-beta-monooxygenase in chromaffin granule ghosts
(American Society for Biochemistry and Molecular Biology, 2004-04-09)The nature of coupling between the uptake and dopamine-beta-monooxygenase (DbetaM) catalyzed hydroxylation of dopamine (DA) was studied in bovine chromaffin granule ghosts. Initial rate and transient kinetics of DA uptake ... -
Kinetic studies of protein-carbohydrate interactions at the bilayer interface of catanionic vesicles
(Wichita State University. Graduate School, 2010-04-23)In this paper, we describe our work on surface functionalization and modification of catanionic vesicles with an aim toward increasing their range of applications. Conventional vesicles are formed from double-tailed ... -
LacI-DNA-IPTG Loops: Equilibria among conformations by single-molecule FRET
(American Chemical Society, 2013-02-13)The E. coli Lac repressor (LacI) tetramer binds simultaneously to a promoter-proximal DNA binding site (operator) and an auxiliary operator, resulting in a DNA loop, which increases repression efficiency. Induction of the ... -
LacI-DNA-IPTG loops: Equilibria among conformations by single-molecule FRET
(Wichita State University. Graduate School., 2012-04-18)The E. coli Lac repressor (LacI) tetramer binds simultaneously to a promoter-proximal DNA binding site (operator) and an auxiliary operator, resulting in a DNA loop, which increases repression efficiency. Induction of the ... -
Latent isocynate derivatives useful for deactivating enzymes
(United States Patent and Trademark Office, 1990-05-29)Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ... -
Linear and differential ion mobility separations of middle-down proteoforms
(American Chemical Society, 2018)Comprehensive characterization of proteomes comprising the same proteins with distinct post-translational modifications (PTMs) is a staggering challenge. Many such proteoforms are isomers (localization variants) that require ... -
A linear S-bridged trinuclear cobalt(III) complex with 2-aminobenzenethiol: synthesis, crystal structure, and spectroscopic characterization
(Taylor & Francis, 2013-09-10)Treatment of cobalt(II) perchlorate hexahydrate with 2 M equiv. of 2-aminobenzenethiol (Habt) in acetonitrile afforded a tricationic tricobalt complex, [Co{Co(abt)3}2](ClO4)3·2CH3CN, by aerial oxidation. The molecular ... -
Lipophilic cationic cyanines are potent complex I inhibitors and specific in vitro dopaminergic toxins with mechanistic similarities to both rotenone and MPP+
(American Chemical Society, 2016-08-10)We have recently reported that simple lipophilic cationic cyanines are specific and potent dopaminergic toxins with a mechanism of toxicity similar to that of the Parkinsonian toxin MPP+. In the present study, a group of ... -
Lipophilic organic cations are novel environmental dopaminergic toxins that may contribute to the etiology of Parkinson's disease
(Wichita State University, 2015-12)Specific uptake through dopamine transporter (DAT) followed by the inhibition of the mitochondrial complex I has been accepted as the mechanism for specific dopaminergic toxicity of 1-methyl-phenylpyridium (MPP+), the most ... -
Liptin interactions with phospholipid membranes as shown by differential scanning calorimetry and fluorescence efflux studies
(Wichita State University, 2020-12)This thesis describes the work done with various liptins on lipid membranes. The liptins are organic molecules designed to interact with bacteria in hopes of reducing the antimicrobial resistance threat. The hypothesis is ... -
Loading and release of doxorubicin with magnetic nanotubes
(John Wiley & Sons, Inc., 2015-03)In this work, we study magnetic nanotubes (MNTs) as drug carriers to control the loading and release of doxorubicin (Dox). The inner surfaces of MNTs where Dox molecules are stored are modified with C18-silane and ... -
Localization of post-translational modifications in peptide mixtures via high-resolution differential ion mobility separations followed by electron transfer dissociation
(Springer International Publishing, 2016-12)Precise localization of post-translational modifications (PTMs) on proteins and peptides is an outstanding challenge in proteomics. While electron transfer dissociation (ETD) has dramatically advanced PTM analyses, mixtures ... -
Long-range stabilization of anthrax protective antigen upon binding to CMG2
(American Chemical Society, 2014-09-30)Protective antigen (PA) mediates entry of edema factor (EF) and lethal factor (LF) into the cytoplasmic space of the cells through the formation of a membrane-spanning pore. To do this, PA must initially bind to a host ... -
Loss of mercaptan sulfur in normal heptane by the use of caustic soda, refractive indices, densities, and viscosities of the lighter mercaptans
(Wichita State University, 1932-05) -
Low-field differential ion mobility spectrometry of dipole-aligned macromolecules
(American Chemical Society, 2020-09-04)Ion mobility spectrometry (IMS) with mass spectrometry has grown into a powerful approach to simplify complex mixtures, disentangle isomers, and elucidate their geometries. Two established branches are linear IMS based on ... -
LRP6 holds the key to the entry of anthrax toxin
(Elsevier, 2006-03-24)In this issue of Cell, it is demonstrated that the low-density lipoprotein receptor-related protein 6 (LRP6) promotes endocytosis of the anthrax toxin into cells. LRP6 acts as a coreceptor with either TEM8 or CMG2, the two ... -
Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses
(United States Patent and Trademark Office, 2016-04-12)Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ... -
Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirus
(Elsevier, 2013-05-16)The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective ... -
Macrocyclic inhibitors of Norovirus 3CL protease
(Wichita State University, 2016-07)Noroviruses are the leading cause of foodborne illness in the U.S., accounting for >21 million infections per year and resulting in >70000 hospitalizations and nearly 800 deaths. Noroviruses are the primary cause of sporadic ... -
Magnetic topological semimetal phase with electronic correlation enhancement in SmSbTe
(Wiley, 2021-08-24)The ZrSiS family of compounds hosts various exotic quantum phenomena due to the presence of both topological nonsymmorphic Dirac fermions and nodal-line fermions. In this material family, the LnSbTe (Ln = lanthanide) ...