Browsing Chemistry and Biochemistry by Title
Now showing items 284-303 of 680
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Identification of isomers by multidimensional isotopic shifts in high-field ion mobility spectra
(American Chemical Society, 2018-07-03)Nearly all molecules incorporate elements with stable isotopes. The resulting isotopologue envelopes in mass spectra tell the exact stoichiometry but nothing about the geometry. Chromatography and electrophoresis at high ... -
Identification of lithic processing stages at Boxed Springs (41UR30)
(Wichita State University, 2022-04-29)Boxed Springs (41UR30) is an early Caddo site (800-1200 CE) located in East Texas that has been a known site since the 1950s and excavated by archaeologists, volunteers, and looters. The site is documented to be poor in ... -
Immobilization and electrochemical redox behavior of cytochrome c on fullerene film-modified electrodes
(Elsevier, 2005-04-01)Two different fullerene film-modified electrodes were prepared and used for surface immobilization and electrochemical property investigation of horse heart cytochrome c (cyt c). Both a pristine fullerene film and ... -
Improving personalized medicine by examining structure-function patterns in the non-conserved regions of lactate dehydrogenase (LDH)
(Federation of American Societies for Experimental Biology, 2017-04)Personalized medicine relies on our ability to make predictions about disease susceptibility based on differences in protein or gene sequences. Recent research has suggested that the non-conserved regions of proteins, those ... -
In search of a COVID-19 vaccine and therapeutics
(Wichita State University, 5/11/2020)Since the emergence of severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, and the end of March 2020, there have been almost 1,500,000 cases of COVID-19 and more than 90,000 deaths worldwide. There are currently ... -
In silico studies of small molecule interactions with enzymes reveal aspects of catalytic function
(MDPI AG, 2017-07-14)Small molecules, such as solvent, substrate, and cofactor molecules, are key players in enzyme catalysis. Computational methods are powerful tools for exploring the dynamics and thermodynamics of these small molecules as ... -
In situ generation of bromine for micelle-assisted bromination and oxidation -- Restricted access to full text
(Wichita State University. Graduate School., 2012-04-18)This paper describes our recent work in which CTAB (cetyltrimethylammonium bromide) micelles are used as catalytic platforms for performing bromination and oxidation reactions in water. The bromide counter ion is used to ... -
Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides
(Elsevier, 2008-01-15)The interaction of a series of 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides with neutrophil-derived serine proteases was investigated. The nature of the amino acid component, believed to be oriented toward the ... -
Incorporation of thiolate donation using 2,2'-dithiodibenzaldehyde: complexes of a pentadentate N2S3 ligand with relevance to the active site of Co nitrile hydratase
(Elsevier, 2007-10-01)The use of 2,2'-dithiodibenzaldehyde (DTDB) as a reactant for incorporating thiolate donors into the coordination sphere of a transition metal complex without the need for protecting groups is expanded to include the ... -
Influence of "alternative" C-terminal amino acids on the formation of [b3 + 17 + Cat]+ products from metal cationized synthetic tetrapeptides
(John Wiley and Sons, 2004-05-01)The aim of this study was to investigate the dissociation patterns, and in particular the relative abundance of [b(3) + 17 + Cat](+), for peptides with C-termini designed to allow transfer of the -OH required to generate ... -
Influence of 2 fluorohistidine on pore formation in the anthrax protective antigen
(2006-07)Bacillus anthracis secretes a toxin which consists of three proteins that is the cause of the anthrax disease symptoms leading to death. They are called the protective antigen (PA), edema factor (EF) and lethal factor (LF). ... -
Influence of a 4-aminomethylbenzoic acid residue on competitive fragmentation pathways during collision-induced dissociation of metal-cationized peptides
(John Wiley and Sons, 2007-01-01)Formation of [bn+17+cat]+ is a prominent collision-induced dissociation (CID) pathway for Li+- and Na+-cationized peptides. Dissociation of protonated and Ag+-cationized peptides instead favors formation of the rival ... -
Influence of a ring substituent on the tendency to form H(2)O adducts to Ag(+) complexes with phenylalanine analogues in an ion trap mass spectrometer
(John Wiley and Sons, 2002-04-01)In a previous report we showed that certain binary Ag(+)-amino acid complexes formed adduct ions by the attachment of a single water and methanol molecule when stored in an ion trap mass spectrometer: complexes with aliphatic ... -
Influence of amino acid side chains on apparent selective opening of cyclic b5 ions
(Springer, 2010-06-01)In this study, the possible influence of acidic, basic, and amide side chains on the opening of a putative macrocyclic b ion (b(5)(+)) intermediate was investigated. Collision induced dissociation (CID) of b(5) ions was ... -
The influence of cation and “alternative” amino acids on the fragmentation pathways of metal cationized and protonated peptides
(Wichita State University, 2008-05)Tandem mass spectrometry and collision-induced dissociation (CID) are the “workhorse” methods for protein identification in proteomics investigations. Recent studies have demonstrated significant differences in the CID ... -
Influence of size on apparent scrambling of sequence during CID of b-type ions
(Springer, 2009-11-01)We investigated the influence of peptide size on the apparent loss of sequence during collision-induced dissociation (CID) of b ions using a group of peptides containing from between 4 and 10 residues. Although scrambling ... -
Infrared multiple photon dissociation spectroscopy of group I and group II metal complexes with Boc-hydroxylamine
(WILEY-BLACKWELL, 2013-08-30)RATIONALE Hydroxamates are essential growth factors for some microbes, acting primarily as siderophores that solubilize iron for transport into a cell. Here we determined the intrinsic structure of 1:1 complexes between ... -
Infrared multiple photon dissociation spectroscopy of sodium and potassium chlorate anions
(John Wiley and Sons, 2010-01-01)The structures of gas-phase, metal chlorate anions with the formula [M(ClO(3))(2)](-), M = Na and K, were determined using tandem mass spectrometry and infrared multiple photon dissociation (IRMPD) spectroscopy. Structural ... -
Infrared multiple-photon dissociation spectroscopy of group II metal complexes with salicylate
(John Wiley and Sons, 2011-07-15)Ion trap tandem mass spectrometry with collision-induced dissociation, and the combination of infrared multiple-photon dissociation (IRMPD) spectroscopy and density functional theory (DFT) calculations, were used to ... -
The inherent high vulnerability of dopaminergic neurons toward mitochondrial toxins may contribute to the etiology of Parkinsons disease
(Medknow, 2016-03-16)Although the exact mechanism(s) of the degeneration of dopaminergic neurons in Parkinson's disease (PD) is not well understood, mitochondrial dysfunction is proposed to play a central role. This proposal is strongly ...