Browsing Chemistry and Biochemistry by Title
Now showing items 75-94 of 682
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Caenorhabditis elegans model studies show $MPP^+$is a simple member of a large group of related potent dopaminergic toxins
(American Chemical Society, 2021-01-26)Although the causes of Parkinson’s disease (PD) are not fully understood, the consensus is that a combination of genetic and environmental factors plays a major role. The discovery that the synthetic chemical, 1-methyl-4 ... -
Carbon nanomaterials for new generation solar cells
(American Chemical Society, 2018)Recently, we invented various types of 3D carbon nanomaterials via invented reactions. Those novel materials possess high elec. cond. and large accessible surface area, which are required for ideal electrode materials. ... -
Carbon nanostructured based donor-acceptor conjugates for light-induced energy and electron transfer
(Wichita State University, 2010-12)The research presented in this dissertation deals with the syntheses, characterization, electrochemical, computational and photophysical studies of carbon nanostructures such fullerenes, single-wall carbon nanotubes (SWCNT) ... -
Carbon nanotube-porphyrin/naphthalocyanine hybrids for photo induced electron transfer studies
(Wichita State University. Graduate School., 2007-04-27)Nanoscience and technology is an emerging field for scientists and engineers due to remarkable mechanical and electronic properties properties of carbon nanotubes (CNTs), and their application in designing optoelectronic ... -
Catalysis of protein folding by chaperones in pathogenic bacteria
(2004-12-14)Molecular chaperones are thought to inhibit off-pathway interactions such as aggregation from occurring without influencing the on-pathway formation of native structure. Here, we present a mechanism whereby the family of ... -
Catanionic surfactant vesicles as a platform for probing protein-carbohydrate multivalent interactions
(Wichita State University, 2011-07)This thesis describes the work on understanding the phase behavior of mixed surfactant systems and on the surface-functionalization and modification of catanionic vesicles with an aim toward probing protein-carbohydrate ... -
Catecholamine disturbance and SH-SY5Y cell toxicity of halogenated 3-amino-2 phenylpropenes
(Wichita State University, 2009-05)Parkinson’s disease (PD) is a progressive neurodegenerative disease that affects between 1% and 2% of the population over age 65. Despite decades of research and the development of many molecular models of PD, there is ... -
CE-LIF coupled with PDMS-interconnected microfluidic systems for rapid separations of neurotransmitters
(Wichita State University. Graduate School, 2014-04-25)In vivo measurement of neurotransmitters in cerebrospinal fluidic (CSF) is an effective method to monitor neuronal activities. Microdialysis coupled with HPLC or capillary electrophoresis (CE) is a powerful approach for ... -
Centrosymmetric or Noncentrosymmetric? Transition Metals Talking in $K_2TGe_3S_8(T = Co, Fe)$
(American Chemical Society, 2021-07-01)Two new quaternary sulfides $K_2TGe_3S_8(T = Co, Fe)$ have been synthesized by a high-temperature solid-state routine and flux growth method. The crystal growth process of $K_2TGe_3S_8(T = Co, Fe)$ was elucidated by in ... -
Chapter 19 -- The Mutagenesis Assistant Program
(Springer International Publishing AG, 2014-06-27)Mutagenesis Assistant Program (MAP) is a web-based statistical tool to develop directed evolution strategies by investigating the consequences at the amino acid level of the mutational biases of random mutagenesis methods ... -
Chapter 3 -- Current Status, Gaps, and Weaknesses of the Mechanism of Selective Dopaminergic Toxicity of MPTP/MPP+
(Elsevier, 2017)Among Parkinson's disease (PD) toxin models, MPTP/MPP+ has been the most popular, extensively characterized, and widely used to identify the cellular mechanisms associated with the selective degeneration of dopaminergic ... -
Characteristics of the mitochondrial and cellular uptake of MPP+ , as probed by the fluorescent mimic, 4'I-MPP+
(2018-08-23)The discovery that 1-methyl-4-phenylpyridinium (MPP+ ) selectively destroys dopaminergic neurons and causes Parkinson’s disease (PD) symptoms in mammals has strengthened the environmental hypothesis of PD. The current ... -
Characterization of a series of 3-amino-2-phenylpropene derivatives as novel bovine chromaffin vesicular monoamine transporter inhibitors
(American Chemical Society, 2003-06-19)A series of 3-amino-2-phenylpropene (APP) derivatives have been synthesized and characterized as novel competitive inhibitors, with K(i) values in the microM range, for the bovine chromaffin granule membrane monoamine ... -
Characterization of alcohol dehydrogenase YqhD, and exploration of the origins of fluorine nuclear magnetic resonance chemical shifts in proteins
(Wichita State University, 2018-07)Alcohol Dehydrogenase YqhD acts as a useful enzyme for the purpose of conversion of alcohols to aldehydes, and visa-versa. It acts on a wide range of substrates, and as such provides a potentially useful platform for ... -
Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor
(Elsevier, 2019-10)Feline infectious peritonitis (FIP) is a highly fatal disease caused by a virulent feline coronavirus in domestic and wild cats. We have previously reported the synthesis of potent coronavirus 3C-like protease (3CLpro) ... -
Characterization of complete histone tail proteoforms using differential ion mobility spectrometry
(American Chemical Society, 2017-05-16)Histone proteins are subject to dynamic post-translational modifications (PTMs) that cooperatively modulate the chromatin structure and function. Nearly all functional PTMs are found on the N-terminal histone domains (tails) ... -
Characterization of PET tracer Flutemetamol (GE-067) binding to Aβ1-40 fibrils
(Wichita State University, 2022-04-29)Alzheimer's disease (AD) is a neurological disorder and the most common cause of dementia. One of the major pathological hallmarks of AD is the deposition of amyloid beta peptide (Aβ) into plaques. In the past decade, ... -
Characterizing dynamical differences between TEM-1 and TEM-52 beta-lactamases
(Cell Press, 2019-02-15)Beta-lactamase, produced in bacteria, defends against beta-lactam antibiotics such as penicillin and cephalosporins by hydrolyzing the beta-lactam ring. This is a primary cause of antibiotic resistance to beta-lactam ... -
Characterizing modified peptides by high-resolution FAIMS followed by electron transfer dissociation
(Wichita State University, 2016-04-29)Full characterization of proteins in living organisms, which is crucial to understanding biomedical processes, remains a stupendous analytical challenge. That especially holds for posttranslational modifications, which ... -
Characterizing the intramolecular H-bond and secondary structure in methylated GlyGlyH+ with H2 predissociation spectroscopy
(Springer, 2011-11)We report vibrational predissociation spectra of the four protonated dipeptides derived from glycine and sarcosine, GlyGlyH(+)center dot(H-2)(1,2), GlySarH(+)center dot(D-2)(2), SarGlyH(+)center dot(H-2)(2), and SarSarH(+)center ...