Chemistry and Biochemistry
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High-definition ion mobility/mass spectrometry with structural isotopic shifts for nominally isobaric isotopologues
(American Chemical Society, 2023-05-04)We had reported the isotopic envelopes in differential IMS (FAIMS) separations depending on the ion structure. However, this new approach to distinguish isomers was constrained by the unit-mass resolution commingling all ... -
A study of the reaction of N-bromosuccinimide with ethyl lactate
(Wichita State University, 1956-08) -
Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)
(Elsevier Ltd, 2023-06-05)The high morbidity and mortality associated with SARS-CoV-2 infection, the etiological agent of COVID-19, has had a major impact on global public health. Significant progress has been made in the development of an array ... -
Thermoelectric materials
(Elsevier Ltd, 2023-01-01)In this chapter, the chemistry of the thermoelectric materials is discussed. First a basic introduction to the thermoelectrics phenomena, fundamental materials parameters, and potential device applications is provided. ... -
Two-dimensional violet phosphorus P11: A large band gap phosphorus allotrope
(American Chemical Society, 2023-03-30)The discovery of novel large band gap two-dimensional (2D) materials with good stability and high carrier mobility will innovate the next generation of electronics and optoelectronics. A new allotrope of 2D violet phosphorus ... -
In search of a COVID-19 vaccine and therapeutics
(Wichita State University, 5/11/2020)Since the emergence of severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, and the end of March 2020, there have been almost 1,500,000 cases of COVID-19 and more than 90,000 deaths worldwide. There are currently ... -
The copper (II) acetohydroxamate complex ion and the preparation of acetohydroxamic acid by Hoffmann's method
(Wichita State University, 1955-03)This research was undertaken to determine the length of time necessary to obtain the maximum yield of acetohydroxamic acid and to study the suspected copper(II) acetohydroxamate complex ion. -
Revisiting two thiophosphate compounds constituting d\(_0\) transition metal HfP\(_2\)S\(_6\) and d\(_{10}\) transition metal α-Ag\(_4\)P\(_2\)S\(_6\) as multifunctional materials for combining second harmonic generation response and photocurrent response
(The Royal Society of Chemistry, 2023-01-18)Two acentric thiophosphate compounds, HfP\(_2\)S\(_6\) and α-Ag\(_4\)P\(_2\)S\(_6\), are revisited and studied as infrared nonlinear optical materials. HfP\(_2\)S\(_6\) and α-Ag\(_4\)P\(_2\)S\(_6\) were structurally ... -
Detecting active deconjugating enzymes with genetically encoded activity-based Ubiquitin and Ubiquitin-like protein probes
(American Chemical Society, 2023-01-17)Post-translational modification of proteins by Ubiquitin (Ub) and Ubiquitin-like proteins (Ubls) can be reversed by deconjugating enzymes, which have been implicated in different pathways and associated with various human ... -
Delineation of isomers and structural elucidation of macromolecules using high-field ion mobility spectrometry with mass spectrometry
(Wichita State University, 2022-12)Ion Mobility Mass Spectrometry (IMS) is a powerful tool that has been utilized to disentangle components out of a complex mixture, distinguish isomers and elucidate geometries. Linear IMS is based on the absolute mobility ... -
Synthesis and characterization of polymer nanocomposite materials for advanced application
(Wichita State University, 2022-12)This research attempted to reduce the effect of Corrosion problem in petroleum sector by developing a new series of polymeric inhibitor and polymer nanocomposites coatings. A major aim of these studies was to synthesis a ... -
An investigation of cyanopyrazole ligands and cyanopyrazole scorpionate ligands in the creation of novel transition metal complexes
(Wichita State University, 2022-12)Pyrazole ligands are popular ligands in inorganic and bioinorganic chemistry due to isoelectronic structural isomers of imidazole. Pyrazole ligands can combine with metals to make mononuclear structures, polynuclear ... -
Boronic acid: A versatile handle for the enrichment of cross-linked peptides
(Wichita State University, 2022-12)Virtually all cellular processes in living organisms rely on protein machinery of complex three-dimensional structures and protein-protein interactions (PPIs). Therefore, significant effort has been devoted for elucidating ... -
The broad antibacterial activity of a small synthetic receptor for cellular phosphatidylglycerol lipids
(Springer Link, 2023-01-09)A small receptor molecule composed of a porphyrin core with tetrakis-ammonium glycine pickets (liptin 3e) appears to target anionic phosphatidylglycerol (PG) lipid head groups through multifunctional binding-pocket ... -
Top-down ion mobility separations of isomeric proteoforms
(American Chemical Society, 2022-12-23)Continuing advances in proteomics highlight the ubiquity and biological importance of proteoforms proteins with varied sequence, splicing, or distribution of post-translational modifications (PTMs). The preeminent example ... -
d$^6$versus d$^{10}$, Which is better for second harmonic generation susceptibility? A Case Study of K$_2$TGe$_3$Ch$_8$ (T = Fe, Cd; Ch = S, Se)
(American Chemical Society, 2022-12-29)Two acentric chalcogenide compounds, K$_2$CdGe$_3$S$_8$ and K$_2$CdGe$_3$Se$_8$, were synthesized via conventional high-temperature solid-state reactions. The crystal structures of K$_2$CdGe$_3$S$_8$ and K$_2$CdGe$_3$S$_8$ ... -
Broad-spectrum cyclopropane-based inhibitors of coronavirus 3C-like proteases: Biochemical, structural, and virological studies
(American Chemical Society, 2022-12-28)The advent of SARS-CoV-2, the causative agent of COVID-19, and its worldwide impact on global health, have provided the impetus for the development of effective countermeasures that can be deployed against the virus, ... -
Potent protease inhibitors of highly pathogenic lagoviruses: Rabbit hemorrhagic disease virus and European brown hare syndrome virus
(American Society for Microbiology, 2022-06-29)Rabbit hemorrhagic disease (RHD) and European brown hare syndrome (EBHS) are highly contagious diseases caused by lagoviruses in the Caliciviridae family. These infectious diseases are associated with high mortality and a ... -
Structure-guided design of potent spirocyclic inhibitors of severe acute respiratory syndrome coronavirus-2 3C-like protease
(American Chemical Society, 2022-06-09)The worldwide impact of the ongoing COVID-19 pandemic on public health has made imperative the discovery and development of direct-acting antivirals aimed at targeting viral and/or host targets. SARS-CoV-2 3C-like protease ... -
A study of the iron (III) acetohydroxamate complex ions
(Wichita State University, 1953-08)
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