Chemistry
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Elemental dependence of structurally specific isotopic shifts in high-field ion mobility spectra
(ACS, 2019-02-01)Nearly all molecules incorporate at least one element with stable isotopes, yielding ubiquitous isotopologic envelopes in mass spectra. Those envelopes split in differential or field asymmetric waveform ion mobility (FAIMS) ... -
Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli
(American Society for Microbiology, 2005-08-31)In Escherichia coli, FkpA, PpiA, PpiD, and SurA are the four known periplasmic cis-trans prolyl isomerases. These isomerases facilitate proper protein folding by increasing the rate of transition of proline residues between ... -
Synthesis and characterization of 2-(2-pyridinyl)pyrazine and 2,2′-bipyrazine derivatives
(Journal of Heterocyclic Chemistry, 2019-01-29)A convenient and high yield preparation of derivatives of 2-(2-pyridinyl)pyrazine and derivatives of 2,2′-bipyrazine compounds from their derivatives of bromopyrazine using Stille coupling is reported. X-ray structures, ... -
Recommendations for reporting ion mobility mass spectrometry measurements
(Wiley, 2019-03-07)Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties ... -
Differential ion mobility separations/mass spectrometry with high resolution in both dimensions
(American Chemical Society, 2019-01-15)Strong orthogonality to mass spectrometry makes differential ion mobility spectrometry (FAIMS) a powerful tool for isomer separations. However, high FAIMS resolution has been achieved overall only with buffers rich in He ... -
How does solvation layer mobility affect protein structural dynamics?
(Frontiers Media S.A., 2018-07-13)Salvation is critical for protein structural dynamics. Spectroscopic studies have indicated relationships between protein and solvent dynamics, and rates of gas binding to heme proteins in aqueous solution were previously ... -
Polypyridyl complexes of uracil derivatives attached to 2,2 '-pyridyl
(American Chemical Society, 2018)Three ligands obtained by the condensation of 2,2'-pyridyl with 5,6-diaminouracil, 5,6-diamino-1-methyluracil and 5,6-diamino-1,3-dimethyluracil were synthesized and crystal structures of the uracil and di-Me ... -
Carbon nanomaterials for new generation solar cells
(American Chemical Society, 2018)Recently, we invented various types of 3D carbon nanomaterials via invented reactions. Those novel materials possess high elec. cond. and large accessible surface area, which are required for ideal electrode materials. ... -
Fenamate protects against 1-methyl-4-phenylpyridinium-induced apoptosis in dopaminergic MN9D cells
(American Chemical Society, 2018)Parkinson's disease (PD) is a neurodegenerative disease caused by the death of dopaminergic neurons in substania nigra. While the causes of PD under mol. level have not been fully identified, it is necessary to identify ... -
Derivatized mixed-ring heterocyclic and antenna carotene ligands
(American Chemical Society, 2018)General synthetic methods have been devised to prep. derivatized mixed-ring heterocyclic and antenna carotene ligands with nitrogen donor atoms. Synthetic methods involve prepn. of intermediate compds. in route to arom. ... -
Seneca Valley Virus Exploits TEM8, a collagen receptor implicated in tumor growth
(Evans DJ, Wasinger AM, Brey RN, Dunleavey JM, St. Croix B and Bann JG (2018) Seneca Valley Virus Exploits TEM8, a Collagen Receptor Implicated in Tumor Growth. Front. Oncol. 8:506, 2018-11-06)Recent studies reveal that Seneca Valley Virus (SVV) exploits tumor endothelial marker 8 (TEM8) for cellular entry, the same surface receptor pirated by bacterial-derived anthrax toxin. This observation is particularly ... -
2-APB and CGP-37157 as neuroprotective agents against the toxicity and uptake of 1-methyl-4-phenylpyridinium in dopaminergic MN9D cell
(American Chemical Society, 2017)Parkinson's disease (PD) is characterized by the death of dopaminergic neurons in the substania nigra, a region in the midbrain. The cause of this dopaminergic cell death is unknown and current therapies have not been ... -
Simple, efficient synthetic route to 2-2 '-bipyrazine derivatives from bromopyrazine for making rhenium and ruthenium dyes
(American Chemical Society, 2017)A simple and efficient synthetic route for syntheses of 2-2'-bipyrazine (bpz) derivs. is described starting with 2-chloropyrazine and 2-methyl-4-carboxypyrazine resulting in 2,2'-bipyrazine, 4-methyl-2,2'-bipyrazine ... -
Protease inhibitors broadly effective against feline, ferret and mink coronaviruses
(Elsevier, 2018-12)Ferret and mink coronaviruses typically cause catarrhal diarrhea in ferrets and minks, respectively. In recent years, however, systemic fatal coronavirus infection has emerged in ferrets, which resembles feline infectious ... -
Advances in structure determination by cryo-EM to unravel membrane-spanning pore formation
(John Wiley and Sons, 2018-08-20)The beta pore-forming proteins (-PFPs) are a large class of polypeptides that are produced by all Kingdoms of life to contribute to their species' own survival. Pore assembly is a sophisticated multi-step process that ... -
Design, synthesis and study of photophysical properties of Re(I) and Ru(II) metal center organometallic complexes as dyes for harvesting sunlight.
(Wichita State University, 2018-07)Due to fascinating physical and photophysical properties, the Re(I) and Ru(II) metal complexes coordinated with small organic molecules, such as 2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyrazine derivatives, are very ... -
Using surfactant-based colloidal systems to promote photoinduced synthesis of silver nanoparticles
(Wichita State University, 2018-07)This thesis focuses on the photo-initiated synthesis of silver nanoparticles in water with low concentration of stabilizing agents to investigate the role that surfactants, specifically their charge, plays in the synthesis. ... -
Characterization of alcohol dehydrogenase YqhD, and exploration of the origins of fluorine nuclear magnetic resonance chemical shifts in proteins
(Wichita State University, 2018-07)This thesis is embargoed to August 2019. -
Characteristics of the mitochondrial and cellular uptake of MPP+ , as probed by the fluorescent mimic, 4'I-MPP+
(2018-08-23)The discovery that 1-methyl-4-phenylpyridinium (MPP+ ) selectively destroys dopaminergic neurons and causes Parkinson’s disease (PD) symptoms in mammals has strengthened the environmental hypothesis of PD. The current ... -
The development of methods to separate and identify variant lipid isomers, utilizing FAIMS and other technologies
(Wichita State University, 2018-05)The development of lipidomics has accelerated over the last decade. However, one of the major sticking points for true identification of individual lipids is the existence of isomers. Due to the complex range of possible ...
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