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dc.contributor.authorBerman, D.A
dc.contributor.authorSobieski, Rodney J.
dc.identifier.citationBerman, D.A., Sobieski, R.J. Depression of lactose hydrolysis by yeasts (1977) Journal of Medical Microbiology. DOI: 10.1099/00222615-10-3-373
dc.descriptionClick on the DOI link to access the article
dc.description.abstractTo investigate the role that the known disaccharidase depression may play in the aetiology of infant gastroenteritis caused by Candida albicans, C. albicans and the rarely pathogenic Saccharomyces cerevisiae were studied by 3 different methods. Both types of yeast significantly depressed the lactose-hydrolysis activity of β-galactosidase, and both depressed lactose hydrolysis in the ligated small intestine of infant rabbits, either in intact animals allowed to survive for 10 h, or in a physiological bath for 20 h. The depression of lactose activity was not temperature dependent; living and inactivated yeast preparations produced comparable degrees of depression of enzyme activity. It is concluded that the depression of lactose hydrolysis is not a virulence factor of C. albicans, but contributes to the often observed disaccharide intolerance associated with candida gastroenteritis in infants.
dc.publisherMicrobiology Society
dc.relation.ispartofseriesJournal of Medical Microbiology
dc.relation.ispartofseriesV. 10, no. 3
dc.subjectCandida albicans
dc.subjectSaccharomyces cerevisiae
dc.subjectTheoretical study
dc.titleDepression of lactose hydrolysis by yeasts
dc.rights.holderCopyright 1977 The Pathological Society of Great Britain and Ireland

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