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dc.contributor.authorHawley, Donna J.
dc.contributor.authorWolfe, Frederick
dc.date.accessioned2019-03-12T20:57:27Z
dc.date.available2019-03-12T20:57:27Z
dc.date.issued1992-09-02
dc.identifier.citationHawley, D.J., Wolfe, F., Sensitivity to change of the Health Assessment Questionnaire (HAQ) and other clinical and health status measures in rheumatoid arthritis results of short-term clinical trials and observational studies versus long-term observational studies (1992) Arthritis & Rheumatism. DOI: 10.1002/art.1790050304
dc.identifier.issn0004-3591
dc.identifier.urihttp://dx.doi.org/10.1002/art.1790050304
dc.identifier.urihttp://hdl.handle.net/10057/15892
dc.descriptionClick on the DOI link to access the article
dc.description.abstractTo obtain evidence concerning short?term and longterm efficacy of clinical and health status measures in rheumatoid arthritis (RA), we conducted two observational studies: a 6-month study of 233 patients receiving methotrexate and a 10-year study of 157 patients receiving multiple treatments in a rheumatic disease clinic. Results of the 6-month study yielded effect sizes for treatment similar to the metaanalyses reported by Weinblatt et al. (Arthritis Rheum 33:1449-1461, 1990) and the controlled trials of methotrexate reported by Weinblatt et al. (Arthritis Rheum 33:330-338, 1990), suggesting that observational studies provide valid measurements of treatment effect. The effect size for the Health Assessment Questionnaire (HAQ) was 0.5. By contrast, the 10-year study suggested that standard clinical variables changed little and were not useful in assessing RA outcome, while the effect size of the HAQ was - 2.39. These data continue to underscore the differences between short-term trials and the long-term outcome of RA, and suggest an important place for the HAQ or similar instruments in all phases of RA evaluation and assessment.
dc.language.isoen-US
dc.publisherAmerican College of Rheumatology
dc.relation.ispartofseriesArthritis and Rheumatism
dc.relation.ispartofseriesV 5, no. 3
dc.subjectAdult
dc.subjectComparative study
dc.subjectData analysis
dc.subjectDisease
dc.subjectDuration drug
dc.subjectEffect
dc.subjectDrug efficacy
dc.subjectErythrocyte sedimentation rate
dc.subjectFemale
dc.subjectGrip strength
dc.subjectHealth status
dc.subjectHuman
dc.subjectJoint examination
dc.subjectLong term care
dc.subjectMajor clinical study
dc.subjectMale
dc.subjectMedical assessment
dc.subjectPhysical capacity
dc.subjectPhysical disability
dc.subjectQuestionnaire
dc.subjectRheumatoid arthritis statistical analysis
dc.titleSensitivity to change of the Health Assessment Questionnaire (HAQ) and other clinical and health status measures in rheumatoid arthritis results of short-term clinical trials and observational studies versus long-term observational studies
dc.typeArticle
dc.rights.holderCopyright 1992 by the Arthritis Health Professions Association


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