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dc.contributor.authorMirzapourrezaei, Seyedali
dc.contributor.authorSalari, Ehsan
dc.identifier.citationMirzapour, S. A. and Salari, E. (2018), Relaxing leaf‐motion restrictions in dynamic multileaf collimator leaf sequencing. Med. Phys., 45: 5263-5276en_US
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractPurpose Methods Traditionally, unidirectional leaf-sweeping schemes have been employed to deliver IMRT plans using the dynamic multileaf collimator (DMLC) technique. The goal of this research is to investigate the potential impact of relaxing the leaf-motion restrictions in DMLC IMRT on the beam-modulation quality and the delivery efficiency. This research relaxes the initial and final leaf-position constraints as well as the unidirectional leaf-motion restriction that have been traditionally imposed on DMLC leaf sequencing and develops exact and heuristic solution approaches to allow for an unconstrained and bidirectional leaf motion. The exact approach employs mixed-integer programming (MIP) techniques and the proposed heuristic method uses stochastic search algorithms while utilizing the special structure of the problem. The trade-off between beam-modulation quality and delivery efficiency is quantified and compared to that of unidirectional leaf-sweeping schemes. Results Conclusions The performance of the developed approaches is tested on liver and head-and-neck cancer cases. Results validate that unconstrained leaf trajectories can significantly improve the beam-modulation quality at small beam-on time values. However, this gain reduces as the available beam-on time increases. Additionally, the proposed heuristic approach can achieve near-optimal solutions with significantly smaller computational effort compared to the MIP solution approach. Unconstrained leaf trajectories have the potential to enhance the fluence-modulation quality for cases in which the available beam-on time is limited. This gain is primarily attributed to the relaxation of the initial and final leaf positions. The unidirectionality restriction alone does not appear to be a limiting factor.en_US
dc.description.sponsorshipNational Science Foundation through Award #1662819.en_US
dc.publisherJohn Wiley and Sonsen_US
dc.relation.ispartofseriesMedical Physics;v.45:no.11
dc.subjectDMLC IMRTen_US
dc.subjectMixed-integer programmingen_US
dc.subjectUnidirectional leaf sweepingen_US
dc.titleRelaxing leaf-motion restrictions in dynamic multileaf collimator leaf sequencingen_US
dc.rights.holder© 2018 American Association of Physicists in Medicineen_US

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    Research works published by faculty and students of the Department of Industrial, Systems, and Manufacturing Engineering

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