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dc.contributor.authorMirzapourrezaei, Seyedali
dc.contributor.authorSalari, Ehsan
dc.date.accessioned2018-03-26T20:01:32Z
dc.date.available2018-03-26T20:01:32Z
dc.date.issued2017-06-14
dc.identifier.citationMirzapourrezaei, Seyedali; Salari, Ehsan. 2017. Bidirectional leaf trajectory optimization approaches for dynamic delivery of intensity-modulated radiotherapy plans. Medical Physics, vol. 44:no. 6:pp 3205-3206en_US
dc.identifier.issn0094-2405
dc.identifier.otherWOS:000426452604140
dc.identifier.urihttps://aapm.onlinelibrary.wiley.com/doi/10.1002/mp.12304
dc.identifier.urihttp://hdl.handle.net/10057/14725
dc.descriptionClick on the URL to access the article (may not be free).en_US
dc.description.abstractPurpose: Traditionally, unidirectional leaf-sweeping schemes have beenused for dynamic deliver y of intensity-modulated radiotherapy (IMRT) plans.This research investigates the potential benefits of bidirectional MLC-leaftrajectories to delivery efficiency and beam-modulation quality particularlywhen the available beam-on time is limited. Methods: This research relaxesthe unidirectional leaf-motion restriction and develops exact and heuristicleaf-sequencing approaches to obtain optimal bidirectional leaf trajectories.In par ticular, the proposed exact and heuristic approaches allow the MLCleaves to start from an arbitrary or pre-specified initial position and movefreely across the radiation field to modulate the desired fluence map. Theexact approach employs mixed-integer programming techniques to solve thearising non-convex optimization problem to a guaranteed optimality gap. Theheuristic methods exploit the special structure of the problem to obtain near-Medical Physics, 44 (6), June 20173205 2017 AAPM Annual Meeting Program 3205 optimal leaf trajectories, while requiring a significantly smaller computa-tional effort.en_US
dc.language.isoen_USen_US
dc.publisherWILEYen_US
dc.relation.ispartofseriesMedical Physics;v.44:no.6
dc.titleBidirectional leaf trajectory optimization approaches for dynamic delivery of intensity-modulated radiotherapy plansen_US
dc.typeAbstracten_US
dc.rights.holder© 2017 American Association of Physicists in Medicineen_US


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