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dc.contributor.authorAdibi, Ali
dc.contributor.authorSalari, Ehsan
dc.identifier.citationAdibi, Ali; Salari, Ehsan. 2017. Spatiotemporally integrated radiotherapy plan optimization. Medical Physics, vol. 44:no. 6:pp 3132-3132en_US
dc.descriptionClick on the URL link to access the article (may not be free).en_US
dc.description.abstractPurpose: This research aims at quantifying the extent of potential therapeu-tic gain that can be achieved from altering the radiation dose distribution overtreatment sessions in fractionated radiotherapy. Methods: A spatiotempo-rally integrated planning approach is developed, where the spatial and tempo-ral dose modulations are optimized simultaneously. The concept ofgeneralized equivalent uniform biologically effective dose (EUBED) is usedto quantify and compare the clinical quality of spatiotemporally heteroge-neous dose distributions in target and critical structures. This gives rise to alarge-scale non-convex treatment-plan optimization problem, which is solvedusing global optimization techniques. The spatiotemporally integratedapproach is used to design plans that deliver distinct dose distributions overtreatment sessions. The plans are compared against those obtained using tra-ditional equivalent uniform dose (EUD)-based planning methods that onlyallow for time-invariant dose distributions.en_US
dc.relation.ispartofseriesMedical Physics;v.44:no.6
dc.titleSpatiotemporally integrated radiotherapy plan optimizationen_US
dc.rights.holder© 2018 American Association of Physicists in Medicineen_US

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