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dc.contributor.authorSumets, P. P.
dc.contributor.authorCater, J. E.
dc.contributor.authorLong, David S.
dc.contributor.authorClarke, R. J.
dc.date.accessioned2018-02-04T23:58:44Z
dc.date.available2018-02-04T23:58:44Z
dc.date.issued2018-03-10
dc.identifier.citationSumets, P., Cater, J., Long, D., & Clarke, R. (2018). Electro-poroelastohydrodynamics of the endothelial glycocalyx layer. Journal of Fluid Mechanics, 838, 284-319en_US
dc.identifier.issn0022-1120
dc.identifier.otherWOS:000419917400001
dc.identifier.urihttp://dx.doi.org/10.1017/jfm.2017.896
dc.identifier.urihttp://hdl.handle.net/10057/14522
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractWe consider pressure-driven flow of an ion-carrying viscous Newtonian fluid through a non-uniformly shaped channel coated with a charged deformable porous layer, as a model for blood flow through microvessels that are lined with an endothelial glycocalyx layer (EGL). The EGL is negatively charged and electrically interacts with ions dissolved in the blood plasma. The focus here is on the interplay between electrochemical effects, and the pressure-driven flow through the microvessel. To analyse these effects we use triphasic mixture theory (TMT) which describes the coupled dynamics of the fluid phase, the elastic EGL, ion transport within the fluid and electric fields within the microvessel. The resulting equations are solved numerically using a coupled boundary-finite element method (BEM-FEM) scheme. However, in the physiological regime considered here, ion concentrations and electric potentials vary rapidly over a thin transitional region (Debye layer) that straddles the lumen-EGL interface, which is difficult to resolve numerically. Accordingly we analyse this region asymptotically, to determine effective jump conditions across the interface for BEM-FEM computations within the bulk EGL/lumen. Our results demonstrate that ion-EGL electrical interactions can influence the near-wall flow, causing it to become reversed. This alters the stresses exerted upon the vessel wall, which has implications for the hypothesised role of the EGL as a transmitter of mechanical signals from the blood flow to the endothelial vessel surface.en_US
dc.description.sponsorshipUniversity of Auckland Doctoral Scholarship. The authors wish to acknowledge the contribution of NeSI high-performance computing facilities to the results of this research. New Zealands national facilities are provided by the NZ eScience Infrastructure and funded jointly by NeSIs collaborator institutions and through the Ministry of Business, Innovation & Employments Research Infrastructure programme, URL https://www.nesi.org.nz.en_US
dc.language.isoen_USen_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofseriesJournal of Fluid Mechanics;v.838
dc.subjectBiological fluid dynamicsen_US
dc.subjectBlood flowen_US
dc.subjectLow-Reynolds-number flowsen_US
dc.titleElectro-poroelastohydrodynamics of the endothelial glycocalyx layeren_US
dc.typeArticleen_US
dc.rights.holder© 2018 Cambridge University Pressen_US


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