Effects of long-term elastic resistance training on oxidative damage of DNA in older adults

Abstract

It is theorized that age-related physiological changes are a consequence of the accumulation of random oxidative damage to deoxyribonucleic acid (DNA), lipids, and proteins. The major by-product of oxidative DNA damage, 8-Oxo-7,8-dihydro-2’-deoxyguanosine (8-oxo-dG), is the most extensively analyzed oxidative stress marker. The concentration of this biomarker increases as age increases. A higher concentration of 8-oxo-dG is related to diseases such as Alzheimer’s, osteoporosis and oncogenesis. Despite the multiple benefits of resistance training on the aging process, the effect upon mitochondrial function and oxidative stress in older adults is unknown.