Browsing BIO Faculty Scholarship by Subject "Wear debris"
Now showing items 1-10 of 10
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Biological responses of preosteoblasts to particulate and ion forms of Co-Cr alloy
(John Wiley & Sons, Inc., 2015-11)This study compared the particulate and ion forms of a cobalt-chrome (Co-Cr) alloy on the differentiation/activation of preosteoblasts. Mouse preosteoblasts (MC3T3-E1) were cultured in an osteoblast-induction medium in the ... -
Cobalt-chromium particles inducing preosteoblasts may aggravate periprosthetic inflammation
(Journal of Clinical Rehabilitative Tissue Engineering Research, 2019)BACKGROUND: Arthroplasty has been the most effective treatment for the end-stage osteoarthritis. However, aseptic loosening is the main long-term complication of arthroplasty. How to ameliorate aseptic loosening is an issue ... -
Current research in the pathogenesis of aseptic implant loosening associated with particulate wear debris
(Acta Orthopaedica Belgica, 2013-02)Periprosthetic osteolysis is the most common long-term complication of a total joint arthroplasty, often resulting in aseptic loosening of the implant, which occurs in up to 34% of younger implant recipients and usually ... -
Different influence of Ti, PMMA, UHMWPE, and Co-Cr particles on peripheral blood monocytes during periprosthetic inflammation
(Wiley Periodicals, Inc., 2015-01)This study investigated cellular trafficking and inflammatory markers in orthopedic biomaterial particle-challenged human peripheral blood monocytes (PBMCs) using a murine immunodeficiency (SCID) model. Periprosthetic ... -
Distinct gene expression of receptor activator of nuclear factor-kappaB and rank ligand in the inflammatory response to variant morphologies of UHMWPE particles
(Elsevier, 2003-11)Recent studies have examined the role of wear debris-induced bone resorption in the aseptic loosening of orthopedic prostheses. Research has shown that inflammation depends not only on the amount of particulate debris, but ... -
The effect of osteoprotegerin gene modification on wear debris-induced osteolysis in a murine model of knee prosthesis failure
(Elsevier, 2009-10)Using an in vivo adeno-associated virus (AAV)-mediated gene transfer technique, this study evaluated the therapeutic effects of an osteoprotegerin (OPG) transgene against orthopaedic wear debris-induced osteolysis in a ... -
Murine model of prosthesis failure for the long-term study of aseptic loosening
(Wiley Periodicals, Inc., 2007-02-02)We examined a novel mouse model of wear debris-induced prosthesis instability and osteolysis, and its application for the evaluation of therapy. A stainless steel or titanium-alloy pin was implanted into the proximal tibia ... -
Particulate and ion forms of cobalt–chromium challenged preosteoblasts promote osteoclastogenesis and osteolysis in a murine model of prosthesis failure
(Wiley, 2018-10-25)This study investigated the interactive behavior of the particulate and ion forms of cobalt–chromium (Co–Cr) alloy challenged preosteoblasts during the process of prosthetic implant loosening. Preosteoblasts were challenged ... -
Polymethylmethacrylate and titanium alloy particles activate peripheral monocytes during periprosthetic inflammation and osteolysis
(Wiley Periodicals, Inc., 2011-05)We investigated the interactions of particulate PMMA or titanium alloy, patient blood monocytes, and periprosthetic tissues using a SCID-hu model of aseptic loosening. Periprosthetic tissues and bone chips obtained at ... -
Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis
(Nature Publishing Group, 2004-03)The current study evaluated the protective effects of anti-inflammatory cytokine gene transfer on osteolysis provoked by orthopedic biomaterial particles using a murine model of inflammatory bone loss. A section of bone ...