Now showing items 1-3 of 3

    • Evaluation of the genotoxic spectrum of cisplatin for Candida albicans 

      Sarachek, Alvin; Henderson, Lori A.; Wilkens, W. E. (University of Cambridge * Faculty Press, 1992)
      The platinum co-ordination complex cisplatin [cis-diamminedichloroplatinum (II)] is a highly effective anticancer drug whose activity derives from its ability to form adducts crosslinking neighbouring purine bases in DNA. ...
    • Genetic destabilization of Candida albicans by hydroxyurea 

      Sarachek, Alvin; Henderson, Lori A.; Eddy, K. B. (University of Cambridge * Faculty Press, 1991)
      Candida albicans is a commensal component of the normal human microflora, but frequently causes infections in persons undergoing treatment for malignancies. The cytotoxicity and genotoxicity of the antineoplastic agent ...
    • Recombinagenicity of caffeine for Candida albicans 

      Sarachek, Alvin; Henderson, Lori A. (SpringerSpringer Netherlands, 1990-05)
      Caffeine at concentrations of 0.5 x 10(-2) M or higher inhibited cell replication and induced gene segregations in Candida albicans cultured on defined complete medium. Both responses increased incrementally with increasing ...