Now showing items 1-5 of 5

    • Evaluation of the genotoxic spectrum of cisplatin for Candida albicans 

      Sarachek, Alvin; Henderson, Lori A.; Wilkens, W. E. (University of Cambridge * Faculty Press, 1992)
      The platinum co-ordination complex cisplatin [cis-diamminedichloroplatinum (II)] is a highly effective anticancer drug whose activity derives from its ability to form adducts crosslinking neighbouring purine bases in DNA. ...
    • Genetic destabilization of Candida albicans by hydroxyurea 

      Sarachek, Alvin; Henderson, Lori A.; Eddy, K. B. (University of Cambridge * Faculty Press, 1991)
      Candida albicans is a commensal component of the normal human microflora, but frequently causes infections in persons undergoing treatment for malignancies. The cytotoxicity and genotoxicity of the antineoplastic agent ...
    • Modification of responses of Candida albicans to cisplatin by membrane damaging antimycotic agents 

      Sarachek, Alvin; Henderson, Lori A. (Wiley-Blackwell Verlag GmbH, 1991-03)
      The genotoxic, antineoplastic platinum coordination complex, cisplatin (cis-diamminedichloroplatinum (II], exists as a positively charged aquated complex in water solution and as a neutral, nonaquated complex in saline ...
    • Recombinagenicity of caffeine for Candida albicans 

      Sarachek, Alvin; Henderson, Lori A. (SpringerSpringer Netherlands, 1990-05)
      Caffeine at concentrations of 0.5 x 10(-2) M or higher inhibited cell replication and induced gene segregations in Candida albicans cultured on defined complete medium. Both responses increased incrementally with increasing ...
    • Segregant-defective heterokaryons of Candida albicans 

      Sarachek, Alvin; Weber, David A. (Springer, 1986)
      Heterokaryons (hets) of the asexual, pathogenic yeast Candida albicans obtained by fusing protoplasts of complementing auxotrophic strains generate large numbers of parental-type auxotrophic monokaryons by random assortment ...