Browsing BIO Faculty Scholarship by Author "Zheng, Xinglong"
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Differential activity of diethylstilbestrol versus estradiol as neonatal endocrine disruptors in the female hamster (Mesocricetus auratus) reproductive tract
Hendry, William J. III; DeBrot, Brian L.; Zheng, Xinglong; Branham, William S.; Sheehan, Daniel M. (Society for the Study of Reproduction, 1999-07)The synthetic estrogen diethylstilbestrol (DES) is a potent neonatal endocrine disruptor in the hamster. To test the specificity of this phenomenon, newborn animals were treated with 100 microgram of either DES or the ... -
Endometrial hyperplasia and apoptosis following neonatal diethylstilbestrol exposure and subsequent estrogen stimulation in both host and transplanted hamster uteri
Hendry, William J. III; Zheng, Xinglong; Leavitt, Wendell W.; Branham, William S.; Sheehan, Daniel M. (American Association for Cancer Research, 1997-05-15)Prenatal exposure to the synthetic estrogen diethylstilbestrol (DES) causes morphogenetic alterations and neoplasia in the human reproductive tract. In the hamster, neonatal DES exposure alters early uterine morphogenesis ... -
Neonatal diethylstilbestrol treatment alters the estrogen-regulated expression of both cell proliferation and apoptosis-related proto-oncogenes (c-jun, c-fos, c-myc, bax, bcl-2, and bcl-x) in the hamster uterus
Zheng, Xinglong; Hendry, William J. III (American Association for Cancer Research, 1997-04)In the Syrian hamster, neonatal diethylstilbestrol (DES) treatment and then postpubertal estrogen stimulation induces hyperplasia plus apoptosis (preneoplastic responses) and ultimately neoplasia in the endometrial epithelial ...