Browsing BIO Faculty Scholarship by Author "Zhang, L."

Now showing items 1-3 of 3

Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model

Zhang, L.; Jia, Tanghong; Chong, A.C.; Bai, Ling; Yu, Haiying; Gong, Weiming; Wooley, Paul H.; Yang, Shang-You (Nature Publishing Group, 2010-10)

Exogenous OPG gene modification appears a therapeutic strategy for osteolytic aseptic loosening. The feasibility and efficacy of a cell-based OPG gene delivery approach were investigated using a murine model of knee ...
Cell-cycle-specific transcription termination within the human histone H3.3 gene is correlated with specific protein-DNA interactions

Taylor, Alan; Zhang, L.; Herrmann, J; Wu, Bei; Kedes, Larry; Wells, D. (Cambridge University Press, 1997-04)

In vitro studies using highly purified calf thymus RNA polymerase II and a fragment spanning the first intron of H3.3 as template DNA have demonstrated the existence of a strong transcription termination site consisting ...
Microcarrier bioreactor culture system promotes propagation of human intervertebral disc cells

Zhang, L.; Ning, Bin; Jia, Tanghong; Gong, Weiming; Cong, M.; Chen, J.F.; Yang, Shang-You (Springer-Verlag, 2010-12)

Background Cell-based tissue engineering has emerged as a potential therapy for intervertebral disc degeneration. However, propagating and maintaining high quantity and quality of the seed cells remains a challenge. Aims To ...