Browsing BIO Faculty Scholarship by Author "Zhang, Kai"
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Biological responses of preosteoblasts to particulate and ion forms of Co-Cr alloy
Yang, Shuye; Zhang, Kai; Li, Fangfang; Jiang, Jianhao; Jia, Tanghong; Yang, Shang-You (John Wiley & Sons, Inc., 2015-11)This study compared the particulate and ion forms of a cobalt-chrome (Co-Cr) alloy on the differentiation/activation of preosteoblasts. Mouse preosteoblasts (MC3T3-E1) were cultured in an osteoblast-induction medium in the ... -
Circulating blood monocytes traffic to and participate in the periprosthetic tissue inflammation
Zhang, Kai; Jia, Tanghong; McQueen, David A.; Gong, Weiming; Markel, David C.; Wooley, Paul H.; Yang, Shang-You (Springer-Verlag, 2009-12)Objective To examine the trafficking of human circulating blood monocytes and their influence on the inflammation of periprosthetic tissues using a novel mouse–human chimera model. Methods Periprosthetic tissue ... -
Cobalt-chromium particles inducing preosteoblasts may aggravate periprosthetic inflammation
Jiang, Jianhao; Li, Peng; Du, Gangqiang; Liu, Hongzhi; Wang, Hui; Zhang, Kai; Yang, Shang-You; Yang, Shuye (Journal of Clinical Rehabilitative Tissue Engineering Research, 2019)BACKGROUND: Arthroplasty has been the most effective treatment for the end-stage osteoarthritis. However, aseptic loosening is the main long-term complication of arthroplasty. How to ameliorate aseptic loosening is an issue ... -
Different influence of Ti, PMMA, UHMWPE, and Co-Cr particles on peripheral blood monocytes during periprosthetic inflammation
Zhang, Kai; Yang, Shang-You; Yang, Shuye; Bai, Ling; Li, Peng; Liu, Dong; Schurman, John R.; Wooley, Paul H. (Wiley Periodicals, Inc., 2015-01)This study investigated cellular trafficking and inflammatory markers in orthopedic biomaterial particle-challenged human peripheral blood monocytes (PBMCs) using a murine immunodeficiency (SCID) model. Periprosthetic ... -
Particulate and ion forms of cobalt–chromium challenged preosteoblasts promote osteoclastogenesis and osteolysis in a murine model of prosthesis failure
Yang, Shuye; Zhang, Kai; Jiang, Jianhao; James, Bonface; Yang, Shang-You (Wiley, 2018-10-25)This study investigated the interactive behavior of the particulate and ion forms of cobalt–chromium (Co–Cr) alloy challenged preosteoblasts during the process of prosthetic implant loosening. Preosteoblasts were challenged ... -
Polymethylmethacrylate and titanium alloy particles activate peripheral monocytes during periprosthetic inflammation and osteolysis
Yang, Shang-You; Zhang, Kai; Bai, Ling; Song, Zheng; Yu, Haiying; McQueen, David A.; Wooley, Paul H. (Wiley Periodicals, Inc., 2011-05)We investigated the interactions of particulate PMMA or titanium alloy, patient blood monocytes, and periprosthetic tissues using a SCID-hu model of aseptic loosening. Periprosthetic tissues and bone chips obtained at ...