Browsing BIO Faculty Scholarship by Author "Yu, Haiying"
Now showing items 1-10 of 10
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Biocompatibility of Poly-ε-caprolactone-hydroxyapatite composite on mouse bone marrow-derived osteoblasts and endothelial cells
Yu, Haiying; Wooley, Paul H.; Yang, Shang-You (BioMed Central, 2009-02-26)Background. Tissue-engineered bone may be developed by seeding the cells capable of both osteogenesis and vascularization on biocompatible composite scaffolds. The current study investigated the performance of mice bone ... -
Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model
Zhang, L.; Jia, Tanghong; Chong, A.C.; Bai, Ling; Yu, Haiying; Gong, Weiming; Wooley, Paul H.; Yang, Shang-You (Nature Publishing Group, 2010-10)Exogenous OPG gene modification appears a therapeutic strategy for osteolytic aseptic loosening. The feasibility and efficacy of a cell-based OPG gene delivery approach were investigated using a murine model of knee ... -
The effect of osteoprotegerin gene modification on wear debris-induced osteolysis in a murine model of knee prosthesis failure
Zhang, Tao; Yu, Haiying; Gong, Weiming; Zhang, Laibo; Jia, Tanghong; Wooley, Paul H.; Yang, Shang-You (Elsevier, 2009-10)Using an in vivo adeno-associated virus (AAV)-mediated gene transfer technique, this study evaluated the therapeutic effects of an osteoprotegerin (OPG) transgene against orthopaedic wear debris-induced osteolysis in a ... -
Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone- hydroxyapatite composites
Yu, Haiying; Matthew, Howard W.; Wooley, Paul H.; Yang, Shang-You (Wiley Periodicals, Inc., 2008-03)The influence of variant pore-size and porosity on the microstructure and the mechanical properties of poly-ε-caprolactone (PCL) and hydroxyapatite (HA) composite were examined for an optimal scaffold in bone tissue ... -
High VEGF with rapid growth and early metastasis in a mouse osteosarcoma model
Yang, Shang-You; Yu, Haiying; Krygier, Jeffrey E.; Wooley, Paul H.; Mott, Michael P. (Hindawi Publishing Corporation, 2007-10-19)A murine model of osteosarcoma was developed to investigate the association between the expression of VEGF and the progression of osteosarcoma. Two human osteosarcoma cell lines with distinct VEGF expressions were introduced ... -
Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization
Yu, Haiying; VandeVord, Pamela J.; Mao, Li; Matthew, Howard W.; Wooley, Paul H.; Yang, Shang-You (Elsevier, 2009-02)Natural bone growth greatly depends on the precedent vascular network that supplies oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue-engineered bone to establish a vascular network ... -
Murine model of prosthesis failure for the long-term study of aseptic loosening
Yang, Shang-You; Yu, Haiying; Gong, Weiming; Wu, Bin; Mayton, Lois; Costello, Richard; Wooley, Paul H. (Wiley Periodicals, Inc., 2007-02-02)We examined a novel mouse model of wear debris-induced prosthesis instability and osteolysis, and its application for the evaluation of therapy. A stainless steel or titanium-alloy pin was implanted into the proximal tibia ... -
Polymethylmethacrylate and titanium alloy particles activate peripheral monocytes during periprosthetic inflammation and osteolysis
Yang, Shang-You; Zhang, Kai; Bai, Ling; Song, Zheng; Yu, Haiying; McQueen, David A.; Wooley, Paul H. (Wiley Periodicals, Inc., 2011-05)We investigated the interactions of particulate PMMA or titanium alloy, patient blood monocytes, and periprosthetic tissues using a SCID-hu model of aseptic loosening. Periprosthetic tissues and bone chips obtained at ... -
Promotion of osteogenesis in tissue-engineered bone by pre-seeding endothelial progenitor cells-derived endothelial cells
Yu, Haiying; VandeVord, Pamela J.; Gong, Weiming; Wu, Bin; Song, Zheng; Matthew, Howard W.; Wooley, Paul H.; Yang, Shang-You (Wiley Periodicals, Inc., 2008-08)In addition to a biocompatible scaffold and an osteogenic cell population, tissue-engineered bone requires an appropriate vascular bed to overcome the obstacle of nutrient and oxygen transport in the 3D structure. We ... -
VEGF blockade decelerates the growth of a murine experimental osteosarcoma
Yin, De-zhen; Jia, Tanghong; Gong, Weiming; Yu, Haiying; Wooley, Paul H.; Mott, Michael P. (Spandidos Publications, 2008-08)Retrovirus-mediated sFlt-1 gene modification was performed to examine the influence of VEGF in controlling the growth of an experimental osteosarcoma in mice. Human osteosarcoma G-292 cells were in vitro infected with ...