Browsing BIO Faculty Scholarship by Author "Yao, Li"
Now showing items 1-20 of 31
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Advances in biological therapy for nucleus pulposus regeneration
Priyadarshani, Priyanka; Li, Yongchao; Yao, Li (Elsevier B.V., 2016-02)Objective: The intervertebral disc (IVD) is composed of the external annulus fibrosus (AF) and the inner gel-like center, the nucleus pulposus (NP). The elastic NP can function to relieve stress and maintain IVD function ... -
Astrocytes migration and their molecular role in the recuperation of damaged nervous tissue
Sai, Haneesha Vishwa; Brice, Ryan; Yao, Li (Nova Science Publishers, Inc., 2022-10-06) -
Bioscaffold-based study of glioblastoma cell behavior and drug delivery for tumor therapy
Tran, Kimmy; Brice, Ryan; Yao, Li (Elsevier, 2021-07-01)Glioblastoma multiforme (GBM) is a severe form of brain cancer with an average five-year survival rate of 6.7%. Current treatment strategies include surgical resection of the tumor area and lining the lesion site with ... -
Collagen matrices mediate glioma cell migration induced by an electrical signal
Yao, Li; Tran, Kimmy; Nguyen, Diana (MDPI, 2022-08-29)Glioma cells produce an increased amount of collagen compared with normal astrocytes. The increasing amount of collagen in the extracellular matrix (ECM) modulates the matrix structure and the mechanical properties of the ... -
Collagen microsphere serving as a cell carrier supports oligodendrocyte progenitor cell growth and differentiation for neurite myelination in vitro
Yao, Li; Phan, Francis; Li, Yongchao (Biomed Central LTD, 2013-09-09)Introduction: Microspheres fabricated from natural materials serve as a promising biodegradable and biocompatible carrier in a small volume for efficient cell delivery to the lesion of the injured neural tissue to generate ... -
The combination of induced pluripotent stem cells and bioscaffolds holds promise for spinal cord regeneration
DeBrot, Ashley; Yao, Li (Wolters Kluwer Medknow Publications, 2018-10-01)Spinal cord injuries (SCIs) are debilitating conditions for which no effective treatment currently exists. The damage of neural tissue causes disruption of neural tracts and neuron loss in the spinal cord. Stem cell ... -
Combining bioscaffolds and iPSCs in the treatment of neural trauma and Alzheimer’s disease
Brice, Ryan; Kehler, Joshua Lee; Yao, Li (Elsevier, 2021-06-04)The discovery of induced pluripotent stem cells (iPSCs) was a breakthrough in biological research poised to be a potential therapy in the field of regenerative medicine. The modality is a personalized therapy due to utilizing ... -
Dental pulp stem cell-derived chondrogenic cells demonstrate differential cell motility in type I and type II collagen hydrogels
Yao, Li; Flynn, Nikol (Elsevier, 2018-06)BACKGROUND CONTEXT: Advances in the development of biomaterials and stem cell therapy provide a promising approach to regenerating degenerated discs. The normal nucleus pulposus (NP) cells exhibit similar phenotype to ... -
Dynamic behaviors of astrocytes in chemically modified fibrin and collagen hydrogels
Seyedhassantehrani, Negar; Li, Yongchao; Yao, Li (Royal Society of Chemistry, 2016-05)Astrocytes play a critical role in supporting the normal physiological function of neurons in the central nervous system (CNS). Astrocyte transplantation can potentially promote axonal regeneration and functional recovery ... -
Dynamic migration of dental pulp stem cell - derived chondrogenic cells in collagen hydrogels
Yao, Li; Flynn, Nikol (Mary Ann Liebert, Inc., 2017-12)The biological approach targets therapy that preserves the intervertebral disc (IVD) function by regenerating the degenerated and damaged nucleus pulposus (NP). Biomaterial hydrogels that mimic the NP extracellular matrix ... -
The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair
Daly, William T.; Yao, Li; Abu-rub, Mohammad T.; O'Connell, Claire; Zeugolis, Dimitrios I.; Windebank, Anthony J.; Pandit, Abhay S. (Elsevier, 2012-10)The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. ... -
The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair
Daly, William T.; Yao, Li; Abu-rub, Mohammad T.; O'Connell, Claire; Zeugolis, Dimitrios I.; Windebank, Anthony J.; Pandit, Abhay S. (Elsevier, 2012-06-24)The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. ... -
Exploration of molecular pathways mediating electric field-directed Schwann cell migration by RNA-Seq
Yao, Li; Li, Yongchao; Knapp, Jennifer R.; Smith, Peter (John Wiley & Sons, Inc., 2015-07)In peripheral nervous systems, Schwann cells wrap around axons of motor and sensory neurons to form the myelin sheath. Following spinal cord injury, Schwann cells regenerate and migrate to the lesion and are involved in ... -
Fabrication and characterization of a protein composite conduit for neural regeneration
Yao, Li; DeBrot, Ashley (American Chemical Society, 2019-09-11)Spinal cord injury (SCI) causes the proliferation of resident microglia and promotes cell migration. Peripheral nerve injury induces the morphological changes and proliferation macrophages. The implantation of neural ... -
Fabrication and characterization of microspheres encapsulating astrocytes for neural regeneration
Berndt, Marcus; Li, Yongchao; Seyedhassantehrani, Negar; Yao, Li (American Chemical Society, 2017-07)Astrocytes play a critical role in supporting the normal physiological function of neurons. Recent studies have revealed that astrocyte transplantation can promote axonal regeneration and functional recovery after spinal ... -
Genetic analysis of the molecular regulation of electric fields-guided glia migration
Yao, Li; Shippy, Teresa D.; Li, Yongchao (Nature Research, 2020-10-08)In a developing nervous system, endogenous electric field (EF) influence embryonic growth. We reported the EF-directed migration of both rat Schwann cells (SCs) and oligodendrocyte precursor cells (OPCs) and explored the ... -
Improved axonal regeneration of transected spinal cord mediated by multichannel collagen conduits functionalized with neurotrophin-3 gene
Yao, Li; Daly, William T.; Newland, Ben; Yao, Sheng; Wang, Wei; Chen, BingKun; Madigan, Nicolas; Windebank, Anthony J.; Pandit, Abhay S. (Nature Publishing Group, 2013-12)Functionalized biomaterial scaffolds targeted at improving axonal regeneration by enhancing guided axonal growth provide a promising approach for the repair of spinal cord injury. Collagen neural conduits provide structural ... -
Improving axon growth of transected spinal cord using multichannel collagen conduits carrying NT-3 gene
Yao, Li; Daly, William T.; Newland, Ben; Yao, Sheng; Chen, BingKun; Madigan, Nicolas; Windebank, Anthony J.; Pandit, Abhay S. (NATURE PUBLISHING GROUP, 2012-05-01) -
Injectable hydrogel provides growth-permissive environment for human nucleus pulposus cells
Priyadarshani, Priyanka; Li, Yongchao; Yang, Shang-You; Yao, Li (John Wiley & Sons, Inc., 2016-02)Degeneration of intervertebral discs (IVDs) results in an overall alteration of the biomechanics of the spinal column and becomes a major cause of low back pain. In this study, an injectable hydrogel composite is fabricated ... -
Intraluminal fiber based scaffolds: a platform for cell migration and axonal regrowth and increased targeted nerve regeneration
Daly, William T.; Yao, Li; Abu-rub, Mohammad T.; O'Connell, Claire; Zeugolis, Dimitrios I.; Windebank, Anthony J.; Pandit, Abhay S. (Wiley-Blackwell, 2012-09)